The absorption characterization effects and mechanism of Radix Angelicae dahuricae extracts on baicalin in Radix Scutellariae using in vivo and in vitro absorption models

Liang, Xin-Li; Liu, Zuliang; Zhu, Jing-Yun; Zhao, Guowei; Yang, Ming; Rong-li, Yin; Yun-chao, Cao; Zhang, Jing; Zhao, Lei

doi:10.1016/j.jep.2011.10.001

Cited by 31 publications

(15 citation statements)

References 14 publications

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“…It is believed that the interaction between herbs could lead to synergistic effects (Cheng, 2015). For HQD, researches have revealed that Angelica dahurica extracts had synergistic action on S. baicalensis by enhancing the intestinal absorption of its major bioactive component baicalin in vivo (Liang et al, 2012). This herbal pair also showed synergistic effect on each other in relieving oxidative stress (Yang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

et al. 2017

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Huangqin decoction (HQD), a traditional Chinese medicine (TCM), has been widely used to treat gastrointestinal syndrome in China for thousands of years. Chemotherapy drug irinotecan (CPT-11) is used clinically to treat various kinds of cancers but limited by its side effects, especially delayed diarrhea. Nowadays, HQD has been proved to be effective in attenuating the intestinal toxicity induced by CPT-11. HQD consists of four medicinal herbs including Scutellaria baicalensis Georgi, Glycyrrhiza uralensis Fisch, Paeonia lactiflora Pall, and Ziziphus jujuba Mill. Due to its complexity, the role of each herb and the multi-herb synergistic effects of the formula are poorly understood. In order to quantitatively assess the compatibility effects of HQD, mass spectrometry-based untargeted metabolomics studies were performed. The serum metabolic profiles of rats administered with HQD, single S. baicalensis decoction, S. baicalensis-free decoction and baicalin/baicalein combination were compared. A time-dependent trajectory upon principal component analysis was firstly used to visualize the overall differences. Then metabolites deregulation score and relative area under the curve were calculated and used as parameters to quantitatively evaluate the compatibility effects of HQD from the aspect of global metabolic profile and the specifically altered metabolites, respectively. The collective results indicated that S. baicalensis played a crucial role in the therapeutic effect of HQD on irinotecan-induced diarrhea. Both HQD and SS decoction regulated glycine, serine and threonine pathway. This study demonstrated that metabolomics was a promising tool to elucidate the compatibility effects of TCM or combinatorial drugs.

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Section: Introductionmentioning

confidence: 99%

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

et al. 2017

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“…Understanding the mechanism of herb formulae could start with an analysis of the simplest form of herb compatibility because herb pairs possess both the characteristics of complex formulae and the feature of simplicity to facilitate research. Therefore, the study of herb pairs may be the foundation and a pointcut in the full investigation of general herb compatibility (Liang et al, 2012). Table 2 Incompatibilities of herb pairs.…”

Section: The Role Of Herb Pairs In Tcmmentioning

confidence: 99%

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Sheng-peng

Tan

et al. 2012

Journal of Ethnopharmacology

268

158

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“…In comparison, the rat in-situ intestinal perfusion model is more reliable since it provides transporters, enzymes and biliary secretion profiles resembling more the in-vivo situation, and utilized for many herbal derivatives, like baicalin extracted from Scutellaria baicalensis Georgi. [27] In most cases, an in-situ intestinal absorption assay is used together with the in-vitro Caco-2 monolayer to better investigate underlying mechanisms of the intestinal absorption of plant derivatives. For example, in the instance of forsythoside A extracted from Forsythia suspensa (Thunb.)…”

Section: Progress Of Intestinal Absorption Of Tcmsmentioning

confidence: 99%

Intestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control

Liu

Lee

Sze

et al. 2012

Journal of Pharmacy and Pharmacology

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Objectives Experimental studies on the pharmacokinetics of traditional Chinese medicines (TCMs) have achieved great progress in recent years. This review aims to summarize the progress made on intestinal absorption and bioavailability of TCMs, and proposes the application of intestinal absorption assays as new tools for the quality and safety control of these medicines. Key findings Since only the absorbed constituents may produce possible therapeutic effect (except those that directly target the digestive tract), intestinal absorption is of utmost importance for the drug action of TCMs, which are usually taken orally. Meanwhile, complicated drug interactions may occur among the multiple ingredients in a herbal mixture. In this regard, the intestinal permeability assays not only provide useful pharmacokinetic data of TCMs, but have potential applications for quality and safety control. Moreover, knockout animals, 2/4/A1 in-vitro cell model and physiologically-based in-silico models based on the online TCM database can be quite useful for the prediction of absorption and bioavailability of TCMs. Summary A variety of in-vivo, in-vitro, in-situ and in-silico models for predicting the intestinal absorption and bioavailability can be applied to study the herbal interactions and screen appropriate biomarkers for the quality and safety control of TCMs.

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The absorption characterization effects and mechanism of Radix Angelicae dahuricae extracts on baicalin in Radix Scutellariae using in vivo and in vitro absorption models

Cited by 31 publications

References 14 publications

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Intestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control

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