The Absorption Characteristics of Paracetamol Tablets in Man

Gwilt, J. R.; Robertson, A.; Goldman, L. J.; Blanchard, Anne

doi:10.1111/j.2042-7158.1963.tb12812.x

Cited by 43 publications

(14 citation statements)

References 7 publications

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“…This is in agreement with previous studies carried out in man (Carlo et al, 1955;Gwilt et al, 1963). There was no evidence from our study that absorption of paracetamol in patients who develop liver damage differs from normal.…”

Section: Discussionsupporting

confidence: 94%

Reduction of Absorption of Paracetamol by Activated Charcoal and Cholestyramine: A Possible Therapeutic Measure

Dordoni¹,

Willson²,

Thompson³

et al. 1973

BMJ

110

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SummaryThe absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours. Introduction A possible therapeutic measure to reduce liver damage after an overdose of paracetamnol (Proudfoot and Wright, 1970;Clark et al., 1973) would be the slowing of the absorption of the drug from the gastrointestinal tract. Oral administration of activated charcoal decreases the absorption of aspirin (Levy and Tsuchiya, 1972), while the anion-exchange resin cholestyramine also decreases the intestinal absorption of some drugs (Gabo et al., 1965). Our in vitro experiments indicated that paracetamol was firmly bound by both of these adsorbents, and we therefore decided to investigate their efficacy in man in slowing the absorption of paracetamol from the gastrointestinal tract.The presumptive absorption of a therapeutic dose of paracetamol in normal subjects was first studied by measuring plasma levels of the drug after an oral dose and then noting the effect on these of activated charcoal and cholestyramine given by mouth at two diffierent times. We also measured the presumptive rate of absorption in patients who had previously taken an overdose of paracetamol to determine whether differences in absorption were responsible for the variable degrees of hepatic damage observed in these patients.

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