The absorption and excretion of fluoride and arsenic in humans

Yu-jian, Zheng; Wu, Jiyao; Ng, J. C.; Wang, Guoquan; Lian, Wei

doi:10.1016/s0378-4274(02)00082-6

Cited by 57 publications

(72 citation statements)

References 4 publications

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“…The antagonistic effects of fluoride and arsenic on inflammatory response in rabbit aorta Simultaneous chronic poisonings with arsenic and fluoride is an emergent endemic disease in China and a few other neighboring countries (Zheng et al 2002). The interaction of arsenic and fluoride has received considerable attention.…”

Section: The Expression Of Adhesion Molecules (Vcam-1 and P-sel) Indumentioning

confidence: 99%

“…Some reports suggested that combined exposure to arsenic and fluoride exhibits some antagonistic effects (Flora et al 2009;Mittal and Flora 2006). Other studies suggested that there was no joint action on the absorption and excretion of these two elements (Zheng et al 2002). Rocha described a synergic effect of fluoride and arsenic on the viability of the neural progenitor cell, and the effect was more marked at the highest concentration, which indicated that the synergic effect might be due to the concentration-dependent interaction (Rocha et al 2011).…”

Section: The Expression Of Adhesion Molecules (Vcam-1 and P-sel) Indumentioning

confidence: 99%

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Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta

Niu

Sun

et al. 2012

Arch Toxicol

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Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis. The aim of the present study is to determine the effect of chronic exposure to arsenic and fluoride alone or combined on inflammatory response in rabbit aorta. We analyzed the expression of genes involved in leukocyte adhesion [P-selectin (P-sel) and vascular cell adhesion molecule-1(VCAM-1)], recruitment and transendothelial migration of leukocyte [interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)] and those involved in pro-inflammatory cytokines [interleukin-6 (IL-6)]. We found that fluoride and arsenic alone or combined increased the expression of VCAM-1, P-sel, MCP-1, IL-8, and IL-6 at the RNA and protein levels. The gene expressions of inflammatory-related molecules were attenuated when co-exposure to the two toxicants compared with just one of them. We also examined the lipid profile of rabbits exposed to fluoride and (or) arsenic. The results showed that fluoride slightly increased the serum lipids but arsenic decreased serum triglyceride. We showed that inflammatory responses but not lipid metabolic disorder may play a crucial role in the mechanism of the cardiovascular toxicity of arsenic and fluoride.

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Section: The Expression Of Adhesion Molecules (Vcam-1 and P-sel) Indumentioning

confidence: 99%

Section: The Expression Of Adhesion Molecules (Vcam-1 and P-sel) Indumentioning

confidence: 99%

Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta

Niu

Sun

et al. 2012

Arch Toxicol

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“…[15] One of the most critically investigated is magnesium fluoride (MgF 2 ), since Mg and F are both naturally occurring elements in the body and the components of degradation remain harmless as the layer corrodes. [16] Previous studies using an MgF 2 protective layer have shown significantly improved corrosion resistance in industrial applications, and slight improvements by way of in vitro and in vivo biological testing. [10,[17][18][19] Bioglass is a bioactive SiO 2 -based coating that is commonly used to facilitate bone adhesion on permanent, metal orthopaedic implants.…”

mentioning

confidence: 99%

Comparison of the Corrosion Behavior of Coated and Uncoated Magnesium Alloys in an In Vitro Corrosion Environment

et al. 2011

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The in vitro degradation of magnesium alloys with various alloying elements, the effect of coatings, and the impact of an altered experimental environment are investigated. LANd442 and Nd2 alloys are subjected to a continuously moving environment during an immersion test allowing flowing SBF. Applying an MgF2 coating to the alloys increases the corrosion resistance of LANd442 but has no effect on the corrosion rate of Nd2 within the period of investigation. It leads to a more‐even degradation with less pitting corrosion in the early stages of corrosion. A bioglass coating on Nd2 increases the corrosion rate. The mass loss, volume loss, and loss in maximum force all show the same trends as the specimens degrade over time.

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“…[ 199,[203][204][205] While magnesium fl uoride positively impacts the corrosion performance of magnesium and its alloys, it also increases the mouse osteoblast-like (MC3T3-E1) and human osteosarcoma (MG63) cells, along with bone tissue compatibility, which has been shown using in vivo and in vitro tests. [ 199,[206][207][208] The MgF 2 coating releases fl uorine as part of the degradation process, which is considered to be non-toxic due to the natural existence of fl uorine in the human body.…”

Section: Reviewmentioning

confidence: 96%

“…[ 199,[206][207][208] The MgF 2 coating releases fl uorine as part of the degradation process, which is considered to be non-toxic due to the natural existence of fl uorine in the human body. [ 199,205 ] Unfortunately, MgF 2 is a comparatively brittle coating [ 203 ] and is not a valid option for sutures, which undergo manifold deformations during stitching and wound closing.…”

Section: Reviewmentioning

confidence: 99%

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

Seitz

Ďurišin

Goldman

et al. 2015

Adv Healthcare Materials

208

158

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Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures. In this Review, biodegradable alloys made of iron, magnesium, and zinc are critically evaluated as potential materials for the manufacturing of soft and hard tissue sutures. In the case of soft tissue closing and stitching, these metals have to compete against currently available degradable polymers. In the case of hard tissue closing and stitching, biodegradable sternal wires could replace the permanent sutures made of stainless steel or titanium alloys. This Review discusses the specific materials and degradation properties required by all suture materials, summarizes current suture testing protocols and provides a well-grounded direction for the potential future development of biodegradable metal based sutures.

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The absorption and excretion of fluoride and arsenic in humans

Cited by 57 publications

References 4 publications

Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta

Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta

Comparison of the Corrosion Behavior of Coated and Uncoated Magnesium Alloys in an In Vitro Corrosion Environment

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

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