The Absorption and Excretion of Orally Administered Nicarbazin by Chickens

Porter, Curt C.; Gilfillan, J. L.

doi:10.3382/ps.0340995

Cited by 41 publications

(23 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 4,6-dimethyl-2-(1H)-pyrimidinone component is rapidly excreted (Porter et al 1955) and this component is rarely detected. Therefore this study was conducted on the effects of cooking on the DNC component of nicarbazin in chicken and egg and the effect of heating DNC in model aqueous and lipid solutions.…”

Section: Introductionmentioning

confidence: 98%

The effect of cooking on veterinary drug residues in food: Nicarbazin (Dinitrocarbanilide component)

Tarbin¹,

Bygrave²,

Bigwood³

et al. 2005

Food Additives and Contaminants

View full text Add to dashboard Cite

The change of concentration of residues of the marker compound for the anti-coccidial drug nicarbazin, N,N'-bis(4-nitrophenyl)urea (dinitrocarbanilide, DNC), was investigated in model oil and aqueous solutions and in chicken muscle and egg. In model aqueous solutions, DNC decreased rapidly in concentration upon heating followed by a much more gradual decomposition. The curves produced when this information was plotted were not typical of exponential decay. In model cooking oil solutions, DNC generally showed a slower decrease in concentration over time when compared with aqueous solutions. DNC residues in egg were stable to microwave cooking and residues in chicken muscle were stable to stewing and microwaving. Other cooking procedures led to a decrease in amount of DNC by 22% to 48% of the total amount of analyte present. Only a small amount (<2%) of residue leached with juices which exuded as the food was cooked.

show abstract

Section: Introductionmentioning

confidence: 98%

The effect of cooking on veterinary drug residues in food: Nicarbazin (Dinitrocarbanilide component)

Tarbin¹,

Bygrave²,

Bigwood³

et al. 2005

Food Additives and Contaminants

View full text Add to dashboard Cite

show abstract

“…As a result, no MRLs have been set for nicarbazin in the European Union. Nicarbazin depletion studies have been conducted in broilers showing that DNC is a more persistent residue than the HDP component in edible tissues [2]. As a result, the FAO/WHO Joint Expert Committee on Food Additives (JECFA) has established a maximum residue limit (MRL) of 200 g/kg for DNC, as the marker residue, in edible tissue (liver and meat).…”

Section: Introductionmentioning

confidence: 99%

Efficient HPLC method for the determination of nicarbazin, as dinitrocarbanilide in broiler liver

Capurro

Danaher

Anastasio³

et al. 2005

Journal of Chromatography B

View full text Add to dashboard Cite

“…The DHP moiety is excreted rapidly following drug withdrawal, but DNC is less rapidly eliminated. Therefore, the FAO/WHO Joint Expert Committee on Food Additives (JECFA) has established DNC as the marker residue for nicarbazin (Porter & Gilfillan 1955). The DNC-DHP complex is 10 times more potent in controlling Eimeria tenella, the primary pathogenic caecal coccidium, than DNC by itself.…”

Section: Introductionmentioning

confidence: 99%

Screening for the coccidiostats halofuginone and nicarbazin in egg and chicken muscle: development of an ELISA

Huet

Mortier

Daeseleire

et al. 2005

Food Additives & Contaminants

View full text Add to dashboard Cite

Nicarbazin and halofuginone have been widely used as coccidiostats for the prevention and treatment of coccidiosis in poultry. It has been shown that accidental cross-contamination of feed can lead to residues of these compounds in eggs and/or muscle. This paper describes a direct competitive assay for detecting halofuginone and nicarbazin, developed as qualitative screening assay. In an optimized competitive ELISA, antibodies showed 50% binding inhibition at approximately 0.08 ng ml(-1) for halofuginone and 2.5 ng ml(-1) for dinitrocarbanilide (marker residue for nicarbazin). Extraction from the matrix was carried out with acetonitrile followed by a wash with hexane. The assay's detection capability (CCbeta) for halofuginone was < 0.5 microg kg(-1) in egg and < 1 microg kg(-1) in muscle. For dinitrocarbanilide, the CCbeta was estimated at < 3 microg kg(-1) in egg and < 10 microg kg(-1) in chicken muscle.

show abstract

The Absorption and Excretion of Orally Administered Nicarbazin by Chickens

Cited by 41 publications

References 2 publications

The effect of cooking on veterinary drug residues in food: Nicarbazin (Dinitrocarbanilide component)

The effect of cooking on veterinary drug residues in food: Nicarbazin (Dinitrocarbanilide component)

Efficient HPLC method for the determination of nicarbazin, as dinitrocarbanilide in broiler liver

Screening for the coccidiostats halofuginone and nicarbazin in egg and chicken muscle: development of an ELISA

Contact Info

Product

Resources

About