The absolute configuration of a hypolipidemic 1-aryl tetralin, nafenopin

Bencze, W. L.; Kisis, B.; Puckett, R. T.; Finch, Neville

doi:10.1016/s0040-4020(01)98751-4

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2018

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Cited by 17 publications

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“…Phenprocoumon ( 5af ) and Nafenopin ( 5ag ) were synthesized in satisfying yields as single regioisomers. Notably, Nafeonpin is commonly synthesized using stoichiometric amounts of aluminum chloride …”

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confidence: 99%

Metal-Free C–O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes

2018

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A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.

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confidence: 99%