“…Abl and Arg also facilitate endocytosis (Jacob et al, 2009;Pendergast, 2006, 2007), autophagy (Yogalingam and Pendergast, 2008), viral (Reeves et al, 2005(Reeves et al, , 2011Swimm et al, 2010) and bacterial uptake (Burton et al, 2003;Elwell et al, 2008;Ly and Casanova, 2009;Napier et al, 2011), and IgG-mediated phagocytosis (Greuber and Pendergast, 2012). We have previously reported that Abl and Arg allow complementary non-redundant processes during phagocytosis and Leishmania uptake (Wetzel et al, 2012). Genetic loss of Arg prevents efficient IgG-mediated phagocytosis and amastigote uptake, whereas loss of Abl reduces C3bi-mediated phagocytosis and L. amazonensis promastigote uptake.…”