The Ability of Xylitol Containing Gum with Calcified Seaweed in Preventing Demineralization of Tooth Surfaces

Miake, Y.; Nozue, Shinji; Moriguchi, Mitsuko; Yamazaki, Takaki; Sawada, Takashi; Yanagisawa, Takaaki

doi:10.2485/jhtb.20.87

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…For ΔZ, the mineral equivalent was calculated using the formula of Angmar et al [ 12 ], using the density of the sample and the aluminum step wedge captured at the same time as the reference. The values were converted to a histogram with a mineral value of 0% and a healthy enamel section of 100% [ 13 ]. Lesion depth (Ld) was defined as the distance from the enamel surface to the location of the lesion where the mineral content was greater than 95% of that in sound enamel [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Improved Enamel Acid Resistance by Highly Concentrated Acidulated Phosphate Sodium Monofluorophosphate Solution

et al. 2022

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Sodium monofluorophosphate (MFP) is a component of fluoride-containing dentifrices and is more biosafe than the conventional sodium fluoride (NaF). MFP can respond not only on the tooth surface layer but also deep into the enamel. We aim to confirm that high concentrations of acid phosphate MFP (AP-MFP, 9000 ppmF), used in professional care, could lead to a highly biosafe fluoride application method that acts through the deep enamel layers. Sample groups were respectively treated in vitro with NaF, acidulated phosphate fluoride (APF), MFP, and AP-MFP, and the samples were compared against an untreated group. Characterizations after fluoride application confirmed that MFP and AP-MFP treatments improved the acid resistance of enamel compared to that of conventional methods. Furthermore, the acid resistance of highly concentrated MFPs improved by using phosphoric acid. Although the acid resistance from the AP-MFP method is not as good as that using APF, AP-MFP can act both on the surface layer and deep into the enamel. Moreover, AP-MFP retains fluoride ions as much as APF does on the tooth surface. The proposed fluoride application method using AP-MFP introduces a dental treatment for acid resistance that is highly biosafe and penetrates deep layers of the enamel.

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Section: Methodsmentioning

confidence: 99%

Improved Enamel Acid Resistance by Highly Concentrated Acidulated Phosphate Sodium Monofluorophosphate Solution

et al. 2022

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“…The remineralization solution used in this experiment was prepared such that the final concentration was Ca: 1 mM, P: 0. 6 mM, F: 0.05 mM (100 ml), and each sample was immersed in 30 ml of the solution 12) . After the remineralization treatment, five samples from each group were immersed in each erosive acid for 6 h at 37 °C to perform the tooth erosion and demineralization treatments.…”

Section: Acid Challenge Experimentsmentioning

confidence: 99%

“…For ΔZ, the mineral equivalent was calculated by the formula of Angmar et al 14) , using the density of the sample and the aluminum step wedge that was captured at the same time as reference. The values were converted to a histogram with the mineral value taken as 0% and the healthy dentin section as 100% 12) . In addition, the depth of the demineralized layer (Ld) was obtained as the length from the original surface (i.e.…”

Section: Contact Microradiogrammentioning

confidence: 99%

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Comparison of Resistance of Dentin to Erosive Acid after Application of Fluoride to Teeth

Eguchi

Satou

Miake

et al. 2020

J. Hard Tissue Biology.

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In recent years, tooth erosion due to tooth root exposure has increased. This is associated with an increase in remaining teeth in the elderly and frequent ingestion of acidic foods. Fluoride application is a clinical method for preventing tooth erosion; however, dentin solubility after topical fluoride application, according to the type of erosive acid, has not been adequately investigated. We studied the characteristics of demineralization and acid resistance of dentin to four erosive acids and evaluated the efficacy of topical fluoride application in preventing tooth erosion. Small blocks with a smooth surface were prepared by mirror-finishing the labial side of a bovine tooth root. In the experimental group, acidulated phosphate fluoride (APF) was applied topically for 4 minutes, while the control group received no fluoride treatment. Both groups were immersed in a remineralization solution for 1 h at 37 °C. Five samples from each group were subjected to tooth erosion and demineralization by immersion in lactic acid, phosphoric acid, acetic acid, and citric acid for 6 h at 37 °C. Demineralization and dentin solubility were evaluated by calculating mineral loss (ΔZ) and lesion depth (Ld) from the average surface roughness (Sa), difference in height profile, and contact microradiogram (CMR). We also performed electron probe microanalysis (EPMA) and X-ray photoelectron spectroscopy (XPS) qualitative analysis to assess fluoride dynamics and properties of the compounds formed on the dentin surface after APF application. Samples with APF application showed greater resistance towards all four erosive acids. While a highly calcified layer was found with lactic and acetic acid, resistance was not adequate against citric acid, which has chelating properties. Fluoridated calcium formed on the tooth surface after topical fluoride application. Fluoride ions are taken up by peritubular dentin through the dentinal tubules, resulting in increased acid resistance.

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“…In our previous study 20,21) , we demonstrated that the abundant quantities of Ca, P and F contained in calcified seaweed enhanced the aciduric properties and remineralization of enamel.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chewing Gum Containing Calcified Seaweed on Remineralization and Acid Resistance of Enamel Subsurface Lesions

Miake

Hiruma

Asada³

et al. 2012

J. Hard Tissue Biology.

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Calcified seaweed contains abundant quantities of calcium, magnesium, phosphate, sodium and fluorine ions. The objective of this study was to investigate the effect of chewing gum containing calcified seaweed on the remineralization and aciduric properties of enamel. For intraoral experiments, enamel blocks prepared from third molars were attached to an appliance. Each block was covered with acid-resistant nail varnish, except for a window measuring 6 x 4 mm. A caries-like lesion was artificially prepared in the window. Participants attached the appliance and chewed gum for 20 min, 4 times a day. The intraoral experiment period was 2 weeks. Half of each window was re-covered with nail varnish. In the aciduric experiment, these blocks were immersed in demineralizing solution. After demineralization, the blocks were embedded in polyester resin and prepared in ground sections. Contact microradiograms of these ground sections were obtained. A high degree of remineralization occurred at the surface and at a deep layer in the remineralized enamel area. In the aciduric experiment area, further demineralization was observed beneath the original demineralized layer, and overall depth of demineralization increased. A thin, highly mineralized layer was observed between the two demineralized layers. The degree of remineralization and aciduric rate with calcified seaweed treatment was higher than that with non-calcified seaweed treatment (p<0.05). These results suggest that chewing calcified seaweed-containing gum significantly enhances the remineralization and acid resistance of enamel by exposure to fluorine ions.

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The Ability of Xylitol Containing Gum with Calcified Seaweed in Preventing Demineralization of Tooth Surfaces

Cited by 9 publications

References 15 publications

Improved Enamel Acid Resistance by Highly Concentrated Acidulated Phosphate Sodium Monofluorophosphate Solution

Improved Enamel Acid Resistance by Highly Concentrated Acidulated Phosphate Sodium Monofluorophosphate Solution

Comparison of Resistance of Dentin to Erosive Acid after Application of Fluoride to Teeth

Effect of Chewing Gum Containing Calcified Seaweed on Remineralization and Acid Resistance of Enamel Subsurface Lesions

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