The ability of neoplastic tissue to produce 12-and 15-Hydroxyeicosatetraenic acids as a test for metastatic activity of human lung tumors

Abstract

The metabolism of 14C-arachidonic acid in cell-free homogenates of 65 primary, primary multiple, and metastatic tumors of human lungs is studied. The biosynthesis of arachidonic acid lipoxygenase metabolites 12-and 15-hydroxyeicosatetraenic acids is suppressed in 9 all metastatic tumors.Key Words: primary and metastatic human lung tumors; metastases; arachidonic acid metabolism; biosynthesis of 12-and 15-hydrox-yeicosatetraenic acids

Serum Free Fatty Acid Biomarkers of Lung Cancer

“…Th ere is considerable basic science evidence that FFAs and the oxidized FFAs HETE and HODE promote tumor development, progression, and metastases in lung cancer using cell culture, 27,28 tissues, [29][30][31] and animal models. 27,[32][33][34] For example, 5-HETE augments lung cancer cell survival, 30,35 12-HETE enhances lung cancer cell adhesion, [36][37][38][39] and 15-HETE promotes human lung cancer metastasis 40 and induces angiogenesis. 41,42 HODE is involved in many types of cancer, although its specifi c role remains unclear.…”