The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action

Yu, Tao; Lee, Sabin; Yang, Woo Seok; Jang, Hyun‐Jae; Lee, Yong Jin; Kim, Tae‐Woong; Kim, Sun Young; Lee, Jaehwi; Cho, Jae Youl

doi:10.1016/j.jep.2011.11.051

Cited by 61 publications

(29 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the inhibitive effect of C. camphora extracts is weaker than that of ACQ, the C. camphora extracts still has the further development and utilization value because of its environmentally friendly and renewable characteristics. Antifungal results reported by Lee et al (2006) and Yu et al (2012) suggested that these extracts have a potential use for developing new natural wood preservatives.…”

Section: Antifungal Activitymentioning

confidence: 96%

Chemical Composition and Antifungal Activity of Extracts from the Xylem of Cinnamomum camphora

Li¹,

Wang²,

Lin³

et al. 2014

BioResources

View full text Add to dashboard Cite

Section: Antifungal Activitymentioning

confidence: 96%

Chemical Composition and Antifungal Activity of Extracts from the Xylem of Cinnamomum camphora

Li¹,

Wang²,

Lin³

et al. 2014

BioResources

View full text Add to dashboard Cite

“…[34] The ethanolic extract of C. cassia (100 µg/mL) has been reported to have anti-inflammatory potential; it can decrease NO production, TNF-α secretion, and prostaglandin E 2 concentration in LPS-activated cells. [35] The essential oils of Cinnamomum osmophloeum twig (50 µg/mL containing L-bornyl acetate 15.89% and cinnamaldehyde 4.07%) have been confirmed to decrease NO production in LPS-stimulated macrophages. This activity is mainly because of its cinnamaldehyde content.…”

Section: µG/mlmentioning

confidence: 96%

Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

View full text Add to dashboard Cite

Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antitumor, anticancer, antidiabetic, and anti-hypertriglyceridemia agent, mainly due to its phytochemical constituents such as phenolic and volatile compounds. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and by solvent extraction. The use of cinnamon in food and its ability to prevent oxidation and inhibit microbial growth are covered in this review. Its bioaccessibility, safety, and consumer acceptance are comprehensively discussed. This review also clearly shows a route to the use of cinnamon as an ingredient in functional foods. ARTICLE HISTORY

show abstract

“…Syk is very quickly activated (within 2 min) by phosphorylation under LPS stimulation condition. Syk activation leads to the subsequent activation of downstream signaling molecules, such as p85, AKT, IKK, PDK1, and NF- κ B, resulting in the induction of expression of proinflammatory genes, such as TNF- α , COX-2, and iNOS, and the production of inflammatory mediators, such as NO and PGE 2 in macrophages [80–83]. Syk is also activated by minimally oxidized low-density lipoprotein (mmLDL).…”

Section: Functions Of Syk In Macrophage-mediated Inflammatory Respmentioning

confidence: 99%

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Son

Ryou

et al. 2014

Mediators of Inflammation

Self Cite

143

175

View full text Add to dashboard Cite

Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers. Spleen tyrosine kinase (Syk) was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses. However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response. This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases.

show abstract

The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action

Cited by 61 publications

References 54 publications

Chemical Composition and Antifungal Activity of Extracts from the Xylem of Cinnamomum camphora

Chemical Composition and Antifungal Activity of Extracts from the Xylem of Cinnamomum camphora

Cinnamon and its derivatives as potential ingredient in functional food—A review

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Contact Info

Product

Resources

About