The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArgand tRNALysisoacceptors in the P site
Kathryn Turnbull,
Helge Paternoga,
Esther von der Weth
et al.
Abstract:The efficiency of translation termination is determined by the nature of the stop codon as well as its context. In eukaryotes, recognition of the A-site stop codon and release of the polypeptide are mediated by release factors eRF1 and eRF3, respectively. Translation termination is modulated by other factors which either directly interact with release factors or bind to the E-site and modulate the activity of the peptidyl transferase center. Previous studies suggested that theSaccharomyces cerevisiaeABCF ATPas… Show more
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