2012
DOI: 10.1371/journal.pone.0049285
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The ABCA1 Gene R230C Variant Is Associated with Decreased Risk of Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease (GEA) Study

Abstract: Background ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated ABCA1 variation in cardiovascular risk. The functional ABCA1/R230C variant is frequent in the Mexican population and has been consistently associated with low HDL-C concentrations. Although it has been associated with other cardiovascular risk factors such as obesity and type 2 diabetes mellitus, it is not known whether it is associated with coronary artery disease (CAD).AimThe purpose of the stu… Show more

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Cited by 78 publications
(69 citation statements)
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References 43 publications
(44 reference statements)
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“…The GEA study was designed to examine the genomic bases of CHD and assess relationships between traditional and emerging risk factors with clinical and subclinical atherosclerotic vascular diseases in an adult Mexican population (17). Briefly, a convenience sample of 1000 CHD patients and 1500 control subjects aged 35-70 years is being recruited from residents in Mexico City.…”
Section: Methodsmentioning
confidence: 99%
“…The GEA study was designed to examine the genomic bases of CHD and assess relationships between traditional and emerging risk factors with clinical and subclinical atherosclerotic vascular diseases in an adult Mexican population (17). Briefly, a convenience sample of 1000 CHD patients and 1500 control subjects aged 35-70 years is being recruited from residents in Mexico City.…”
Section: Methodsmentioning
confidence: 99%
“…The primary aim of the GEA Study was to investigate genetic factors associated with premature CAD, subclinical atherosclerosis and other coronary risk factors, in the Mexican population. The selection of patients from the GEA Study has been described previously [26]. All participants provided written informed consent, and the study complied with the Declaration of Helsinki and was approved by the Ethics Committee of the Instituto Nacional de Cardiología ''Ignacio Ch avez'' (INCICH).…”
Section: Study Populationmentioning
confidence: 99%
“…Patients and controls with previous history of liver, thyroid, malignant, or chronic renal disease, in addition those under corticosteroids treatment were excluded [22]. Physicians assessed all clinical variables and performed data collection.…”
Section: Methodsmentioning
confidence: 99%