Derelict mining districts represent anthropogenically influenced landscapes that are often characterized by important geological, ecological, environmental, industrial, cultural, and archeological values. Nevertheless, after mining activities cease, several environmental problems are left behind, associated with soil and water pollution, hydrogeological instability, subsidence, ecosystem damages, and landscape degradation or devastation. In this article we present a case study focused on a sulfide mining district (Petronio and Gromolo valleys, Genova) located on the ophiolitic sequences of the Northern Apennines (Eastern Liguria, Italy), with the aim of applying a GIS (Geographic Information System)-based model for the complete census of derelict mines and for the assessment of their geoheritage and geotourist values, potential risks, and environmental impact. All information has been integrated to produce a multicriteria approach for the evaluation of hazards and/or critical issues and geoheritage values. Based on the results obtained in this pilot area, an integrated cultural and touristic route has been proposed, which combines several points of interest (POIs) chosen within an area of about 8 km2.