The 9p21 Locus as a Potential Therapeutic Target and Prognostic Marker in Colorectal Cancer

Bahrami, Afsane; Hassanian, Seyed Mahdi; Khazaei, Majid; Gharib, Masoumeh; Rahmani, Mahsa; Fiuji, Hamid; Jazayeri, Mir Hadi; Moetamani‐Ahmadi, Mehrdad; Ferns, Gordon A.

doi:10.2217/pgs-2017-0096

Cited by 11 publications

(5 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colorectal cancer (CRC) is one of the most common human malignancies globally (Bahrami et al, ). Approximately one half of the Western population develops a colorectal tumor by the age of 70 and approximately 1 out of 10 of these individuals progress to malignancy (Kinzler & Vogelstein, ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Bahreyni

Rezaei

Bahrami

et al. 2018

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

Aberrant microRNA (miR) expression is implicated in multiple human malignancies. miR‐21, acting as a proto‐oncogene, is involved in a variety of cellular processes and tumorigenesis and is frequently overexpressed in some cancer types. Several tumor suppressors, metastatic, and apoptotic genes have been identified as miR‐21 targets, including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell death 4, Integrin‐β4, and E‐cadherin thereby regulating tumor growth, invasion, and metastasis. There is a growing evidence that miR‐21 expression is associated with clinical outcomes in patients with colorectal cancer (CRC). In this review, we summarize the potential diagnostic, prognostic, and therapeutic values of miR‐21 in CRC progression for a better understanding and hence a better management of this disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Bahreyni

Rezaei

Bahrami

et al. 2018

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Wound scratch assay (M) was used to detect cell wound healing rate (N). development of breast cancer, renal cell carcinoma, lung adenocarcinoma and colorectal cancer [40][41][42]. N-cadherin is high expression in many tumors, including colorectal cancer [43].…”

Section: Discussionmentioning

confidence: 99%

Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal

et al. 2022

View full text Add to dashboard Cite

Background The decoction of Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) has been reported as a potential antitumor agent for colorectal cancer (CRC) in experimental and clinical studies, but its underlying mechanism is still unclear. Methods The current research aims to explore the potential of Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction (AR decoction) in the treatment of CRC and explore the underlying mechanism. SW620 cells were transient transfection to overexpress or knock down wnt 5 or β-Catenin. Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) -containing serum (AR-CS) was used to interfere with SW620 cells. Additional AR-CS, Wnt5 inhibitor (IWP-4), and β-Catenin inhibitor (JW55) were used to intervene in SW620 cells. Furthermore, subcutaneously injection of SW620 cells into the right flank of nude mice replicated xenograft mice, which were treated with AR decoction for 21 days. Results AR-CS significantly reduced the mRNA and protein expression levels of Wnt5, β-Catenin, ARF6, and N-Cadherin in SW620 cells, while inhibiting the proliferation and migration of SW620 cells. In cells overexpressing Wnt5 or β-Catenin, these effects of AR-CS were significantly suppressed. On the contrary, the inhibitory effect of AR-CS on the mRNA and protein levels of ARF6 and N-Cadherin and cell proliferation and migration of SW620 was enhanced, when Wnt5 or β-Catenin were knocked down or suppressed by the inhibitors. Moreover, in the mouse model of xenograft tumors, AR decoction not only reduced the tumor volume and inhibited the mRNA levels and protein levels of Wnt5, β-Catenin, ARF6, and N-Cadherin in the tumor, but also inhibit the protein levels of LRP5, LRP6, TCF-4, and LEF1.The histopathology of mice also showed increased apoptosis in tumor tissues, and AR decoction treatment did not cause pathological damage to the kidney and liver. Conclusions Our results provide evidence that AR decoction inhibits Wnt5/β-catenin signaling and inhibits the development of CRC, which is a promising traditional medicine in the clinical treatment of CRC.

show abstract

“…Gu and colleagues indicated chromosome 9p21 as a molecular target for benzopyrene-induced chromosome aberration associated with the risk of bladder cancer (26). The same mechanism is confirmed to be responsible for colorectal adenoma formation in patients with elevated benzopyrene intake (27).…”

Section: Benzenopyrene and Aromatic Hydrocarbonsmentioning

confidence: 96%

Scented Candles as an Unrecognized Factor that Increases the Risk of Bladder Cancer; Is There Enough Evidence to Raise a Red Flag?

Adamowicz

Juszczak²,

Poletajew

et al. 2019

Cancer Prevention Research

View full text Add to dashboard Cite

The causes of bladder cancer are not yet fully uncovered, however the research has identified a number of factors that may increase the risk of developing this cancer. The chemical carcinogenesis of bladder cancer due to chronic exposure to aromatic hydrocarbons has been well-established. The identification of this correlation led to an improvement of safety measures in chemical industry and a gradual decrease of bladder cancer cases among workers. Nevertheless, in the majority of bladder cancer cases, the specific cause of the disease still can't be specified. It makes the question of unrecognized factors asso-ciated with bladder cancer development even more relevant. Taking under consideration known chemical carcinogenesis of bladder cancer, this minireview takes under investigation the possible link between using scented candles and a risk of bladder cancer development. Burning scented candles contain many of the substances that are associated with a bladder cancer. Furthermore the scented candles are not only very popular but also widely available on the market, with limited quality regulations and unspecified raw materials determining a spectrum of potentially dangerous substances emitted during burning.

show abstract

The 9p21 Locus as a Potential Therapeutic Target and Prognostic Marker in Colorectal Cancer

Cited by 11 publications

References 76 publications

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal

Scented Candles as an Unrecognized Factor that Increases the Risk of Bladder Cancer; Is There Enough Evidence to Raise a Red Flag?

Contact Info

Product

Resources

About