The −974C&gt;A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients

Vargas‐Alarcón, Gilberto; Vallejo, Maité; Posadas‐Romero, Carlos; Juárez-Rojas, Juan Gabriel; Peña‐Duque, Marco Antonio; Carrillo-Sánchez, Silvia; Pérez-Méndez, Óscar; Fragoso, José Manuel

doi:10.1016/j.gene.2013.09.003

Cited by 14 publications

(11 citation statements)

References 32 publications

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“…In this context, Pawlik et al demonstrated that there is no association among the NOS3 rs1799983 and rs2070744 polymorphisms and unstable angina [ 32 ]. Additionally, Vargan-Alarcon et al found no differences regarding the eNOS polymorphism distribution between patients with ACS and healthy control groups [ 33 ]. Although Jo et al found that the -786TC polymorphism had a frequent association with myocardial infarction in the Korean population [ 7 ], the eNOS4a allele, linked to the same polymorphism, showed a protective effect for ACS in the Korean population [ 34 ], while Hibi et al found no association between the same polymorphism and myocardial infarction [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation

Severino

D’Amato

Prosperi

et al. 2021

JCDD

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IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such as interethnic differences. Validation of results in larger cohorts and new populations is needed. The aim of this study is to evaluate the associations between the allelic variants of the eNOS rs1799983 single-nucleotide polymorphism, IHD susceptibility and its clinical presentation. Methods: A total of 362 consecutive patients with suspected myocardial ischemia were enrolled. Patients were divided into three groups: G1, coronary artery disease (CAD); G2, coronary microvascular dysfunction (CMD); and G3, a control group with anatomically and functionally normal coronary arteries. Analysis of three allelic variants, GT, GG and TT, of rs1799983 for the NOS3 gene, encoding for eNOS, was performed. Results: rs1799983_GT was significantly more expressed by the ischemic groups (G1 and G2) compared to G3. The TT variant was significantly more expressed by the G1 group, compared to the G2 group. Among ischemic patients, GT was significantly more expressed in patients with acute coronary syndrome (ACS) presentation, compared to other clinical presentations. In the multivariate analysis, the allelic variant GT was found to potentially represent an independent predictor of IHD and ACS presentation. Conclusion: The presence of the SNP rs1799983_GT, encoding for eNOS, is an independent risk factor for IHD and, remarkably, for ACS presentation, independently of cardiovascular risk factors. These results may be useful for the prediction of IHD development, particularly with an acute clinical manifestation. They may allow the early identification of patients at high risk of developing IHD with an ACS, promoting a genetic-based prevention strategy against IHD.

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Section: Discussionmentioning

confidence: 99%

Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation

Severino

D’Amato

Prosperi

et al. 2021

JCDD

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“…These results corroborate the data obtained from patients with ACS in different countries (Australia, Pakistan, Mexico and Japan) who indicated that the majority of the patients were hypertensive, varying between 56.5% in Japan and 68.0% in the Mexico. 14,35,37,38 For the Ministry of Health, this disease is responsible for at least 25% of the deaths due to ACS. 39 In the present study it was verified that the majority of patients with ACS are dyslipemic (64.0%), similar data were verified by Feijó et al, 40 Rodrigues et al, 41 and Andrade et al, 42 who studied Brazilian patients with CDs and found that 50.5%, 73.9% and 60.1%, respectively, were dyslipemic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Silva¹,

Araújo²,

Soares³

et al. 2019

IJCS

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Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs).Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods:A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife -PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant. Results:In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions:The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.

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“…34 In addition, rs1476046 was associated with endothelial dysfunction in pre-pubertal children, particularly in the presence of obesity. 29 While the rs3087459 polymorphism was studied in patients with coronary artery disease 26 , there are no reports of associations with T2DM or DN.…”

Section: Discussionmentioning

confidence: 99%

“…EDN1 has been identifi ed as a strong candidate gene for cardiovascular and renal disease. Various single nucleotide polymorphisms (SNPs) in the EDN1 gene were linked to arterial hypertension 22,23 , heart failure 24 , coronary artery disease 25,26 , left ventricular hypertrophy 27 , modifi cation of vascular reactivity 28 , endothelial dysfunction 29 , progression of atherosclerosis 30 , as well as with accelerated decline in kidney function in the chronic glomerulonephritis patients 31 , and with end stage renal disease attributed to hypertension 32 . In addition, EDN1 genetic variability was related to microvascular complications of T2DM such as diabetic retinopathy 33 , and DN 34 .…”

mentioning

confidence: 99%

Endothelin-1 Gene Polymorphisms rs5370, rs1476046, and rs3087459 are not Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

et al. 2017

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Materials and methods:The study population consisted of 651 Caucasian subjects with T2DM of more than 10 years' duration: 276 patients with DN (cases) and 375 patients without evidence of DN (controls). Polymorphisms in ET-1 (EDN1) gene, rs5370, rs1476046, and rs3087459, were studied. Results: Genotype distributions of the studied polymorphisms showed no significant diff erence between cases and controls. Conclusions: We provide evidence that the rs5370, rs1476046, and rs3087459 polymorphisms of EDN1 gene are not risk factors for DN in Caucasians with T2DM.

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The −974C>A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients

Cited by 14 publications

References 32 publications

Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation

Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation

Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Endothelin-1 Gene Polymorphisms rs5370, rs1476046, and rs3087459 are not Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

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