The 88-kDa Eales’ protein in serum is a complex of haptoglobin, complement C3, and galectin-1 as identified by liquid chromatography coupled mass spectrometry

Ramanujam, Saravanan; Bharathselvi, Muthuvel; Aravind, C Babu; Biswas, Jyothirmay; Konerirajapuram, N Sulochana

doi:10.1002/prca.201600068

Prot. Clin. Appl.

2016

DOI: 10.1002/prca.201600068

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The 88-kDa Eales’ protein in serum is a complex of haptoglobin, complement C3, and galectin-1 as identified by liquid chromatography coupled mass spectrometry

Saravanan Ramanujam

Muthuvel Bharathselvi

C Babu Aravind

et al.

Abstract: The 88-kDa protein, a complex of haptoglobin, complement C3, and galectin-1, may play a potential role in ED pathogenesis while levels galectin-1 and haptoglobin may serve as potential biomarker of ED.

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References 28 publications

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Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications

Chatchen

Svasti

2017

Proteomics Clinical Apps

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Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic range of protein concentration hinders the detection of low abundance proteins. Plasma prefractionation methods serve as indispensable tools to reduce plasma complexity, allowing the opportunity to explore tissue-derived proteins which leak into the circulation. This review summarizes common approaches in plasma prefractionation methods for proteomic analysis and then discusses some considerations in plasma prefractionation for clinical applications, reviewing some examples of its use in clinical situations.

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Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications

Chatchen

Svasti

2017

Proteomics Clinical Apps

View full text Add to dashboard Cite

show abstract

Quantitative proteomic analysis of rat retina with experimental autoimmune uveitis based on tandem mass tag (TMT) peptide labeling coupled with LC-MS/MS

Liu

Yin

Wei

et al. 2020

Journal of Chromatography B

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Galectin-1 as a predictive biomarker in ovarian cancer

et al. 2021

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Aim There is an urgent need to set up a useful biomarker for ovarian cancer. Galectin-1 is a promising carbohydrate-binding protein which plays a remarkable role in various malignancies yet its clinical significance is questionable. In this study, we have tested the clinical implications of serum Galectin-1 levels in patients with ovarian tumours. Main methods Serum Galectin-1 levels were quantified in 84 newly diagnosed ovarian tumour patients and 20 healthy controls by Enzyme Linked Immuno Sorbent Assay during the course of the disease. Therefore the samples were taken at diagnosis, after surgery and after chemotherapy. Key findings The Galectin-1 levels were found to be associated with various variables of Ovarian Cancer patients. The levels were found to be prominently high in postmenopausal patients. Galectin-1 levels were raised in epithelial ovarian tumours with significantly high levels in serous subtype. A decrease in Galectin-1 levels post-surgical intervention and after receiving chemotherapy was found. Galectin-1 levels evidently distinguished between normal, benign, malignant and metastatic cases as compared to CA125 levels. Galectin-1 demonstrated to be a better biomarker than CA125 according to the Receiver Operating Characteristic (ROC) curve analysis. Significance The study emphasizes that serum Galectin-1 may serve as a better surrogate biomarker in Ovarian Cancer for early detection, discriminating between malignant and benign abdominal masses and monitoring the progression of the disease and response to treatment.

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The 88-kDa Eales’ protein in serum is a complex of haptoglobin, complement C3, and galectin-1 as identified by liquid chromatography coupled mass spectrometry

Abstract: The 88-kDa protein, a complex of haptoglobin, complement C3, and galectin-1, may play a potential role in ED pathogenesis while levels galectin-1 and haptoglobin may serve as potential biomarker of ED.

Cited by 3 publications

References 28 publications

Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications

Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications

Quantitative proteomic analysis of rat retina with experimental autoimmune uveitis based on tandem mass tag (TMT) peptide labeling coupled with LC-MS/MS

Galectin-1 as a predictive biomarker in ovarian cancer

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