The 8‐oxoguanine DNA <i>N</i>‐glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease

Tanrikulu, Sevda; Doğru‐Abbasoğlu, Semra; Özderya, Ayşenur; Ademoğlu, Evin; Karadağ, Berrin; Erbil, Yeşim; Uysal, Müjdat

doi:10.1002/cbf.1742

Cited by 13 publications

(17 citation statements)

References 30 publications

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“…Tanrikulu et al assessed hOGG1 Ser326Cys polymorphism (rs1052133) as a candidate risk factor for GD. They found that Cys/Cys genotype had a 3.5-fold (95% CI: 2.10–6.01, P < 0.001) and the Cys allele had 1.83-fold (95% CI: 1.43–2.34, P < 0.001) increase in the risk for developing Grave's disease in their population [46]. The Ser326Cys polymorphism in hOGG1 gene was shown to reduce the hOGG1 activity in both in vitro and in vivo studies [46].…”

Section: Oxidative Stress In Graves' Disease and Retroorbital Tissuesmentioning

confidence: 99%

“…They found that Cys/Cys genotype had a 3.5-fold (95% CI: 2.10–6.01, P < 0.001) and the Cys allele had 1.83-fold (95% CI: 1.43–2.34, P < 0.001) increase in the risk for developing Grave's disease in their population [46]. The Ser326Cys polymorphism in hOGG1 gene was shown to reduce the hOGG1 activity in both in vitro and in vivo studies [46]. As the production of 8-oxoG is increased both in retroorbital fibroblasts and in urine of patients with GD and correlates with the disease activity, it could be argued that reduced hOGG1 activity causes increased DNA damage and increased OS making subject more susceptible to development of Graves' orbitopathy [43, 44].…”

Section: Oxidative Stress In Graves' Disease and Retroorbital Tissuesmentioning

confidence: 99%

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The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

Žarković

2012

Journal of Thyroid Research

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Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo.

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Section: Oxidative Stress In Graves' Disease and Retroorbital Tissuesmentioning

confidence: 99%

Section: Oxidative Stress In Graves' Disease and Retroorbital Tissuesmentioning

confidence: 99%

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

Žarković

2012

Journal of Thyroid Research

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“…Considering the DNA repair efficiency, homozygous hOGG1 1245 CC genotype has the highest DNA repair activity followed by the heterozygous hOGG1 1245 CG genotype and then the homozygous hOGG1 1245 GG genotype in order [ 9 ]. This discrepancy in hOGG1 repair activity implies that hOGG1 1245 GG genotype with lower efficiency in DNA repair might be related to a higher level of 8-OHdG in human tissues [ 10 ], and may contribute to the development of several human degenerative diseases, including type 2 diabetes mellitus [ 11 ], Huntington’s disease [ 12 ], chronic obstructive pulmonary disease [ 13 ], Graves’ ophthalmopathy [ 14 ], and higher susceptibility to cancer formation, including lung cancer [ 15 ] and esophageal squamous cell carcinoma [ 16 ]. However, the role of hOGG1 C1245G polymorphism in the pathogenesis of SLE has remained obscure.…”

Section: Introductionmentioning

confidence: 99%

The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus

Lee

Lin

Lee

et al. 2015

IJMS

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We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with SLE. A total of 45 healthy controls and 85 SLE patients were recruited. The C1245G polymorphism of the hOGG1 gene was determined by direct sequencing. The frequency of occurrence of the hOGG1 1245 GG genotype in SLE patients was 31.8% (27/85), which is lower than that of healthy controls of 53.3% (24/45). Thirty-three (33/85, 38.8%) SLE patients developed lupus nephritis. Significantly, SLE patients harboring the hOGG1 1245 GG genotype had a higher incidence to develop lupus nephritis than did those harboring the hOGG1 1245 CC or CG genotype (15/27, 55.6% vs.18/58, 31.0%, p = 0.031). Divided into subgroups, SLE patients harboring the hOGG1 1245 GG genotype had the highest plasma levels of 8-OHdG among patients with all genotypes, with regard to the coexistence of lupus nephritis (p = 0.020, ANOVA), including those with nephritis harboring the hOGG1 1245 CC or CG genotypes (p = 0.037), those without nephritis harboring the hOGG1 1245 GG genotype (p = 0.050), and those without nephritis harboring the hOGG1 1245 CC or CG genotype (p = 0.054). We conclude that the C1245G polymorphism of hOGG1 may be one of the factors that confer the susceptibility to lupus nephritis and modulate the plasma level of 8-OHdG in patients with SLE.

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“…The role of accumula on of oxida ve DNA damage, however, was unequivocally confirmed, specifically for Grave's ophtalmopathy [131]. The homozygous Cys/Cys genotype of the Ser326Cys polymorphism in the hOGG1 gene was found to be associated with nearly 4-fold increase in the risk for developing Graves' disease [132].…”

Section: Neil Genesmentioning

confidence: 98%

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Chakarov¹,

Petkova²,

Russev³

2014

Biodiscovery

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The first part of this paper reviews the major achievements in the rapidly expanding field of research of individual capacity for repair of genotoxic damage. The issues of individual repair capacity are addressed from mul ple sides, analyzing the impact of the heritable components of the capacity for detoxifica on of genotoxic compounds, on the one hand (determining the risk for occurrence of DNA damage) and of the capacity for repair of DNA damage (when it has already occurred), on the other hand. The role of the capacity for repair of damage to DNA is discussed in the cons tu on of the risk for development of disease (mainly cancer, but also other common diseases and condi ons, such as diabetes, atherosclerosis and cardiovascular disease) and as a major factor in the outcomes of genotoxic therapies (eligibility for therapy with specific agents, risk for severe adverse effects, post-therapeu c survival rates, etc.). The paper contains an extensive list of biomarkers (mainly DNA polymorphisms, but also enzymes and other phenotypic markers, such as markers of the capacity for self-renewal of cell popula ons) that may be poten ally applicable in the assessment of the risk for carcinogenesis or for development other types of human disease.The second part of the paper provides a brief glimpse of the basic methodology used to obtain experimental results in assessment of the efficiency of DNA repair in living cells for research and diagnos c purposes.Cita on: Chakarov S, Petkova R, Russev GCh. Individual capacity for detoxifica on of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair.

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The 8‐oxoguanine DNA N‐glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease

Cited by 13 publications

References 30 publications

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease

The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

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