The −786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports

Gómez‐Gallego, Félix; Ruiz, Jonatan R.; Buxens, Amaya; Artieda, Marta; Arteta, David; Santiago, Catalina; Rodríguez-Romo, Gabriel; Lao, José I.; Lucía, Alejandro

doi:10.1007/s00421-009-1166-7

Cited by 58 publications

(66 citation statements)

References 35 publications

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“…Studies performed in Spanish and Italian athletes showed that the -786 T allele (which leads to increased gene function ) is associated with power-oriented elite athletic status [8,25]. These findings might partly explain the role that NO and NOS play in muscle hypertrophy, which is clearly an important phenotype trait in power athletic events [8]. For instance, NOS activity is important for the up-regulation of contractile protein gene expression [24].…”

Section: Discussionmentioning

confidence: 99%

“…Notably, the NOS3 -786 T/C polymorphism results in altered transcription and promoter activity [18], and is strongly involved in skeletal muscle glucose uptake during exercise [17]. Studies performed in Spanish and Italian athletes showed that the -786 T allele (which leads to higher gene transcription and promoter activity) is associated with power-oriented athletic status [8,25], whereas another study suggested the -786C allele results in reduced NOS3 gene transcription and promoter activity and is associated with improved aerobic capacity in hypertensive men [2].…”

Section: Introductionmentioning

confidence: 99%

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The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

et al. 2012

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The NOS3-786 T/C polymorphism (rs2070744) is a candidate to explain individual variations in sports related phenotypes. We determined the genotype and allele frequency of NOS3-786 T/C in a group of 60 male professional elite soccer players.Their results were compared with those of 100 world-class endurance athletes, 53 elite power athletes, and 100 sedentary, healthy men (controls) of the same Caucasian (Spanish) origin. There were significant differences in genotype frequencies between soccer players, controls, endurance and power elite athletes (all P≤0.02). These results were confirmed when we analysed allelic frequencies (all P<0.01). The likelihood of having the C allele was higher in soccer players compared with (i) controls [odds ratio (OR), 2.165, 95% confidence interval (CI): 1.362-3.441], (ii) endurance athletes (OR:1.879, 95%CI: 1.184-2.984), and (iii) power athletes (OR: 4.032, 95%CI: 2.307-7.047). In conclusion, the -786C allele is associated with the status of being an elite soccer player, compared with non-athletic controls and also with elite endurance and power athletes. More research is needed in other groups of elite soccer players in order to replicate the results of the present study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

et al. 2012

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“…Hence, the NOS3 gene, due to its central role in the production of NO in the vascular endothelium [6], became a candidate gene for association with athlete status or athletic performance. Indeed, NOS3 has been associated with endurance performance, endurance elite status [6,30], power elite athlete status [31,32] and elite soccer player's status [33], being an example of "mixed" exercise phenotype requiring both endurance and power abilities.…”

Section: Introductionmentioning

confidence: 99%

Endothelial nitric oxide synthase g894t (rs1799983) gene polymorphism in polish athletes

et al. 2013

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The NOS3 gene has been associated with athletic endurance performance and elite power athletic status. With respect to NOS3 G894T and its relation to athletic performance or status, results across various studies have not been consistent. Therefore, the lack of consistency among previous studies prompted us to design a case-control study in a Polish Caucasian population to examine the relationship between the NOS3 G894T polymorphism and athletes' status, i.e. type and intensity of exercise performed (poweroriented, “mixed” power/endurance activity, endurance-oriented) and the possible association between the G894T variant and athletic performance. The case-control study was performed in a group of 360 Polish athletes (cases) of the highest nationally competitive standard (male n=156 and female n=67) and 191 unrelated, sedentary control subjects. The G894T genotype and allele distributions differed significantly between power-oriented (P=0.009, P=0.003), “mixed” (P=0.021, P=0.009), endurance (P=0.043, P=0.014) athletes when compared to control subjects (P values for genotypes and alleles, respectively). There were no significant differences between elite and sub-elite athletes in any group. The over-representation of the GG genotype and G allele in all athletes suggests that the G894 allele may favour all types of sports, however, the strongest predisposition was seen among power-oriented athletes.

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“…Although sprint performance is likely a polygenic trait, only a few single nucleotide polymorphisms (SNP's), namely ACTN3 R577X [1][2][3][4], ACE I/D [5][6][7] and more recently eNOS -786 T/C [8] and, IL-6 -174G/C ( ), were found to be associated with sprint performance.…”

Section: Introductionmentioning

confidence: 99%

Is the interaction between HIF1A P582S and ACTN3 R577X determinant for power/sprint performance?

et al. 2010

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Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates gene expression in response to hypoxia, and has been associated with athletic performance. The aims of this study were 1) to determine the frequency distribution of HIF1A Pro582Ser (rs11549465) polymorphism among 155 Israeli athletes (sprinters and endurance athletes) and 240 healthy controls and 2) to analyze the influence of the interaction between HIF1A Pro582Ser and ACTN3 R577X (rs1815739) genotypes on sprint performance. There were no differences across the HIF1A genotype and allele frequencies among endurance athletes, sprinters and controls. Similarly, no differences were found between the subgroups of top-level and national-level endurance athletes, or between top-level and national-level sprinters.Conversely, interaction effects were found between HIF1A Pro582Ser and ACTN3 R577X polymorphisms and sprinters. The proportion of HIF1A Pro/Pro + ACTN3 R/R genotypes was significantly higher in sprinters than in endurance athletes and healthy controls (P=0.002). In addition, the odds ratio for HIF1A Pro/Pro + ACTN3 R/R genotype carriers being a sprinter was 2.25 (95% confidence interval 1.24-4.1), and for HIF1A Pro/Pro + ACTN3 R/R genotype carriers being an endurance athlete was 0.5 (95% confidence interval 0.2-1.24). We conclude that HIF1A Pro582Ser polymorphism by itself is not critical in determining sprint performance. However, sprinter performance is determined by the interaction between the wild-type HIF1A Pro/Pro genotype and ACTN3 RR genotype.3

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The −786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports

Cited by 58 publications

References 35 publications

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

Endothelial nitric oxide synthase g894t (rs1799983) gene polymorphism in polish athletes

Is the interaction between HIF1A P582S and ACTN3 R577X determinant for power/sprint performance?

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