MANY FACTORS, INCLUD-ing age, female sex, body mass index, and comorbid medical conditions, are known to be associated with a decrement in exercise capacity, as reflected by a decrease in maximal workload achieved or maximal oxygen consumption. [1][2][3][4][5][6] Aerobic exercise capacity decreases progressively with age and is associated with reductions in functional capacity, increases in disability, and decreases in independence and quality of life. Determining the most important parameters affecting exercise performance, especially in relation to age, is complex, given the numerous confounding factors. The most consistently reported mechanism contributing to this decrease in exercise capacity with aging is a reduction in maximal heart rate; this appears to be a nonmodifiable and inevitable consequence of aging.7 Similarly, the difference in exercise capacity between men and women has largely been attributed to nonmodifiable differences in cardiac output and skeletal muscle mass. 8,9 Identifying potentially reversible mechanisms underlying the decline in maximal exercise capacity with aging and between men and women could have important implications.Elucidating the mechanisms of cardiac-related exercise limitation has been technically difficult to date. Previous studies have suggested that measurements of left ventricular systolic function do not predict maximal exercise time in individuals with normal or impaired left ventricular systolic function.10,11 However, differences in exercise capacity related to small changes in ejection fraction within the normal range would require evaluation in a large population. Doppler echocardiography can now characterize left ven- Context Limited information exists regarding the role of left ventricular function in predicting exercise capacity and impact on age-and sex-related differences.Objectives To determine the impact of measures of cardiac function assessed by echocardiography on exercise capacity and to determine if these associations are modified by sex or advancing age.Design Cross-sectional study of patients undergoing exercise echocardiography with routine measurements of left ventricular systolic and diastolic function by 2-dimensional and Doppler techniques. Analyses were conducted to determine the strongest correlates of exercise capacity and the age and sex interactions of these variables with exercise capacity.
Setting Large tertiary referral center in Rochester, Minnesota, in 2006.Participants Patients undergoing exercise echocardiography using the Bruce protocol (N=2867). Patients with echocardiographic evidence of exercise-induced ischemia, ejection fractions lower than 50%, or significant valvular heart disease were excluded.
Main Outcome Measure Exercise capacity in metabolic equivalents (METs).Results Diastolic dysfunction was strongly and inversely associated with exercise capacity. Compared with normal function, after multivariate adjustment, those with moderate/severe resting diastolic dysfunction (−1. P=.007) were similarly associated with a redu...