Cell Reports volume 5, issue 1, P237-247 2013 DOI: 10.1016/j.celrep.2013.08.049 View full text
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Katherine E. Sloan, Markus T. Bohnsack, Nicholas J. Watkins

Abstract: SummarySeveral proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11. Here, we report that RPL5 and RPL11 regulate p53 from the context of a ribosomal subcomplex, the 5S ribonucleoprotein particle (RNP). We provide evidence that the third component of this complex, the 5S rRNA, is critical for p53 r…

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