1983
DOI: 10.1083/jcb.97.1.244
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The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies.

Abstract: The keratins are a highly heterogeneous group of proteins that form intermediate filaments in a wide variety of epithelial cells. These proteins can be divided into at least seven major classes according to their molecular weight and their immunological reactivity with monoclonal antibodies. Tissue-distribution studies have revealed a correlation between the expression of specific keratin classes and different morphological features of in vivo epithelial differentiation (simple vs. stratified; keratinized vs. … Show more

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Cited by 338 publications
(179 citation statements)
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“…K5 and K14 are expressed in the basal layer of all stratified squamous epithelia, and have been considered to be the pair of keratins that typify these tissues (Moll et al, 1982a;Nelson and Sun, 1983). Thus, we anticipated that there might be abnormalities in the architecture of other stratified K14 -/-tissues.…”
Section: The Effects Of K14 Ablation On Other Stratified Squamous Epimentioning
confidence: 99%
“…K5 and K14 are expressed in the basal layer of all stratified squamous epithelia, and have been considered to be the pair of keratins that typify these tissues (Moll et al, 1982a;Nelson and Sun, 1983). Thus, we anticipated that there might be abnormalities in the architecture of other stratified K14 -/-tissues.…”
Section: The Effects Of K14 Ablation On Other Stratified Squamous Epimentioning
confidence: 99%
“…Basal cells are distinguished by an intracellular cytoskeleton composed of a relatively dispersed, but extensive, network of keratin filaments. These filaments are made of a 1:1 ratio of two distinct keratin prote~ns: K5 (58 kD) and K14 (50 kD) (Nelson and Sun, 1983). Additional hallmarks of basal cells, also common to spinous cells, are desmosomes, which are calcium-activated membrane junctions that interconnect the cells into a three-dimensional lattice (for review, see Franke et al, 1987).…”
Section: The Program Of Terminal Differentiationmentioning
confidence: 99%
“…Based on sequence, these proteins fall into two groups, type I and type II (1), which form heteropolymers. K5 (type II) and K14 (type I) are the pair expressed in the mitotically active, basal layer (2). As keratinocytes commit to differentiate, they switch off expression of K5 and K14 and 1.…”
Section: Introductionmentioning
confidence: 99%