The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease

Martínez-Clemente, Marcos; Clària, Joan; Titos, Esther

doi:10.1097/mco.0b013e32834777fa

Cited by 53 publications

(42 citation statements)

References 47 publications

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“…The role of adipokines in initiating inflammation is increasingly being recognized in human and veterinary fields. 10,16 Clinically, these 2 possibilities would be impossible to differentiate. As 3 of these 4 dogs had clinical signs (abdominal pain, vomiting) for more than 3 days, lack of opportunity for inflammation to develop seems unlikely.…”

Section: Discussionmentioning

confidence: 99%

Association between canine pancreatic-specific lipase and histologic exocrine pancreatic inflammation in dogs

2012

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Abstract. The current study aimed to determine the specificity, and to a lesser extent the sensitivity, of canine pancreaticspecific lipase (cPL) concentration in dogs with various disease conditions. Dogs were presented for postmortem examination and had serum collected for cPL concentration within 6 hr preceding death or immediately postmortem. Pancreatic tissue was collected postmortem, and sections from the left lobe, right lobe, and body of the pancreas were examined histologically. Inflammation and fibrosis in each section were assessed to determine a total pancreatic inflammatory score and pancreatic fibrosis score in each dog. Correlations between these scores and the cPL concentration were made, as well as determination of specificity. A total of 32 dogs were included in the analysis, 20 of whom had no to minimal pancreatic inflammation. The specificity of cPL with a cutoff value of 200 µg/l was 80% (95% confidence interval [CI]: 56-94%), while with a cutoff of 400 µg/l, the specificity was 90% (95% CI: 68-99%). There was a significant but rather low correlation between cPL concentration and the pancreatic inflammation score, but not with the fibrosis score. Canine pancreatic-specific lipase concentration has good specificity overall in dogs without pancreatitis. This test is less useful in dogs with milder pancreatitis, and both falsepositive and false-negative results occur. Results indicated that dogs with clinical signs suggestive of pancreatitis would require abdominal imaging in addition to serum cPL testing to evaluate the cause (or causes) of clinical signs.

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Section: Discussionmentioning

confidence: 99%

Association between canine pancreatic-specific lipase and histologic exocrine pancreatic inflammation in dogs

2012

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“…The presence of macrophages in visceral adipose tissue and pro-inflammatory TNF-alpha and leucotriene production has been strongly associated with T2DM development (Martínez-Clemente et al, 2011). The relationship between visceral adipose tissue accumulation and chronic inflammation has been reviewed recently (Gong and Muzumdar, 2012).…”

Section: Inflammatory Pathomechanisms Leading To T2dmmentioning

confidence: 99%

“…Finally, in silico identification of miR-296-5p as a potential regulator of lipoapoptosis has been demonstrated to be suppressed by a saturated free fatty acid (palmitate), and miR-296-5-p expression was reduced in liver samples of NASH patients (Martínez-Clemente et al, 2011).…”

Section: Micro Rnas Involved In Nonalcoholic Steatohepatitismentioning

confidence: 99%

Role of Regulatory Micro RNAs in Type 2 Diabetes Mellitus–Related Inflammation

Hamar

2012

Nucleic Acid Therapeutics

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“…Furthermore, leukotrienes have been found very essential as inflammatory mediators in mediating HFD induced insulin resistance [34]. Adipocytes in obesity were found as the major source of leukotrienes [35]. Hence, leukotriene inhibitors could reduce the levels of TNF-α, IL-6 and MCP-1.…”

Section: Discussionmentioning

confidence: 99%

Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation

Abdel‐Latif

2015

International Immunopharmacology

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The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease

Abstract: Modulation of lipoxygenases represents a novel target in the prevention of adipose tissue and hepatic dysfunction related to the metabolic syndrome.

Cited by 53 publications

References 47 publications

Association between canine pancreatic-specific lipase and histologic exocrine pancreatic inflammation in dogs

Association between canine pancreatic-specific lipase and histologic exocrine pancreatic inflammation in dogs

Role of Regulatory Micro RNAs in Type 2 Diabetes Mellitus–Related Inflammation

Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation

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