The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat

Dourish, C T; Cooper, Steven J.; Gilbert, François; Coughlan, J.; Iversen, Susan D.

doi:10.1007/bf00735881

Cited by 51 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, we have observed similar increases in the consumption of food pellets after comparable doses of 8-OH-DPAT and gepirone (Dourish et al 1985a;Gilbert and Dourish 1987). Similar- (Dourish et al 1988). However, experiments which have examined the effects of 8-OH-DPAT on the consumption of sweetened liquids have produced conflicting results.…”

Section: Di~u~ionmentioning

confidence: 54%

“…This observation indicates that 8-OH-DPAT does not elicit non-specific chewing. These data, together with the recent reports that 8-OH-DPAT increases milk intake (Dourish et al 1988) and sham feeding , provide compelling evidence that hyperphagia induced by the drug is due to a specific action on brain 5-HT mechanisms which control feeding.…”

Section: Di~u~ionmentioning

confidence: 87%

“…Thus, it was reported that 8-OH-DPAT (over a wide dose range) did not increase the intake of palatable sucrose and saccharin solutions in food deprived rats (Fletcher 1987;Montgomery et al 1988). In contrast, 8-OH-DPAT increased the consumption of palatable sweetened milk in food deprived rats and in non-deprived rats (Dourish et al 1988). However, the effects of the drug on milk intake were relatively small and evident over a narrow dose range (0.03-4).04 rag/ kg) compared to the effects on food pellets (Dourish et al 1985a;Dourish et al 1988).…”

Section: Di~u~ionmentioning

confidence: 99%

“…In contrast, 8-OH-DPAT increased the consumption of palatable sweetened milk in food deprived rats and in non-deprived rats (Dourish et al 1988). However, the effects of the drug on milk intake were relatively small and evident over a narrow dose range (0.03-4).04 rag/ kg) compared to the effects on food pellets (Dourish et al 1985a;Dourish et al 1988). In contrast, the dose-response curves and magnitude of 8-OH-DPAT-and gepirone-induced increases in the consumption of liquid chow in the present study were very similar to those observed in previous experiments using food pellets (see Dourish et al 1985a;Gilbert and Dourish 1987).…”

Section: Di~u~ionmentioning

confidence: 99%

See 3 more Smart Citations

8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test

1988

View full text Add to dashboard Cite

There have been recent claims that the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicits chewing and eating of solid but not liquid foods. Therefore, the effects of 8-OH-DPAT and another 5-HT1A agonist gepirone on the consumption of a liquid chow diet, by free feeding male rats, were examined. Both drugs produced a dose-dependent increase in the consumption of liquid diet during a 2 h test. The doses of 8-OH-DPAT and gepirone which increased liquid diet intake in this study were in the same range as those which were found previously to increase food pellet consumption by free feeding rats. The effects of 8-OH-DPAT were also examined in a feeding choice test in which free feeding animals were allowed to choose between food pellets and a liquid chow diet. In this test, 8-OH-DPAT significantly increased total food intake (liquid plus pellet) but had no significant effect on the consumption of either liquid or pellet diets when analysed separately. Thus, there were large individual differences in diet choice after 8-OH-DPAT injection. However, rats did not consistently choose to eat food pellets rather than the liquid diet, as would be predicted if the drug elicited chewing rather than eating. These results provide strong evidence that 8-OH-DPAT elicits a behaviourally specific hyperphagia and not chewing or gnawing.

show abstract

Section: Di~u~ionmentioning

confidence: 54%

Section: Di~u~ionmentioning

confidence: 87%

Section: Di~u~ionmentioning

confidence: 99%

Section: Di~u~ionmentioning

confidence: 99%

See 2 more Smart Citations

8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test

1988

View full text Add to dashboard Cite

show abstract

“…These studies in humans confirm reports in animals that m-CPP decreases food intake, including carbohydrates, protein, and fat in a mixed testmeal. [Neuropsychopharmacology 11:63-71, 1994J man generally leads to increased satiety (Blundell 1984(Blundell , 1986, with the exception of 5-HT IA receptor activation that induces feeding in animals in specific paradigms (Dourish et al 1985(Dourish et al , 1986(Dourish et al , 1988. Conversely, attenua tion of 5-HT neurotransmission by various methods leads to decreased satiety and increased food consump tion and weight gain (Blundell and Latham 1978, 1982Blundell 1984Blundell , 1986.…”

mentioning

confidence: 99%

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Brewerton

Murphy

Jimerson

1994

Neuropsychopharmacol

View full text Add to dashboard Cite

A wealth of data support a role for serotonin (5-HT) function in the mediation of satiety responses, that are impaired in patients with bulimia nervosa. Testmeal results are presented in which 26 bulimic patients and 17 normal controls were given in randomized, double-blind-fashion, placebo, and the 5-HT agents m-chlorophenylpiperazine (m-CPP, 0.5 mglkg p.o.) and L-tryptophan (L-TRP, 100 mglkg I. V.). Three and one-half hours after drug administration, subjects were allowed to eat and lib from a standardized testmeal of 3,500 calories, after which postprandial vomiting was not allowed. M-CPP, but not L-TRP, significantly decreased meal size in the combined group, the controls, and to a lesser extent, the bulimics (p � .06). Maximum m-CPP Serotonergic manipulations are known to result in marked changes in feeding behaviors, particularly sati ety responses (Blundell 1977(Blundell , 1984(Blundell , 1986Blundell and Latham, 1978, 1982Latham and Blundell 1979;Samanin et al. 1982;Silverstone and Goodall 1986;Garattini et al., 1988Garattini et al., , 1989, which are dysfunctional in bulimic patients (Owen et al. 1985;Chiodo and Latimer 1986;Kissileff et al. 1986). Pharmacologic en hancement of 5-HT neurotransmission in animals and concentrations were inversely correlated to the number of calories consumed in the total group. Following m-CPP, there were significant decreases in carbohydrate, protein, and fat intake in the total group of subjects. There were also trends for decreased carbohydrate and protein intake in the bulimics following m-CPP. There were trends for both m-CPP and L-TRP to reduce fat intake in the controls. Differences in the effects between m-CPP and L-TRP are likely due to differential involvement of 5-HT receptor subtypes at presynaptic and postsynaptic sites. These studies in humans confirm reports in animals that m-CPP decreases food intake, including carbohydrates, protein, and fat in a mixed testmeal.

show abstract

Effects of gepirone on ethanol consumption, exploratory behavior, and motor performance in rats

Knapp¹,

Benjamin²,

Pohorecky³

1992

Drug Development Research

View full text Add to dashboard Cite

Activation of 5-HT receptors via reuptake inhibition, precursor loading, or inhibition of catabolism have consistently resulted in decreases in ethanol preference in rats. The objective of the present studies was to determine whether activation of the EB-HT,~ receptor with gepirone, a selective agonist, decreases ethanol preference. Preference was first evaluated for ethanol solutions from 3 to 11 Yo, in a free-choice situation with ethanol solution or tapwater available in the home cage. Male Sprague-Dawley rats consumed the most ethanol solution relative to water at a concentration of 6%. When ethanol (6% solution) was available to ethanol-habituated rats in a 1 -hr restricted access situation, subjects consumed 5.9 * 0.4 ml. Pretreatment with gepirone (0.46-4.6 mg/kg IP) resulted in a dose-dependent reduction in ethanol consumption in the restricted-access paradigm. The 5-HT reuptake inhibitor fluoxetine also resulted in dose-related decreases in ethanol consumption in restricted access. A subsequent experiment using a lower dose of fluoxetine also found a suppressive effect on ethanol intake. A single daily dose of gepirone failed to decrease the consumption of 6% ethanol when it was continuously available in the home cage. The short half-life of gepirone might explain its lack of effect in continuous access with only one daily dose. Gepirone decreased open-field activity at higher (2.3 to 4.6-mg/kg) doses, but did not affect rotorod performance at any dose (4.6-9.2 mg/kg) tested, whereas haloperidol (0.025-1 .O mg/kg) significantly decreased time on the rotorod. These results suggest that 5-HT,, receptor activation decreases ethanol intake in limited access and that the motorically disrupting effects of gepirone are not manifest under these conditions. 0 1992 Wiley-Liss, Inc.

show abstract

The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat

Cited by 51 publications

References 14 publications

8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test

8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test

Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls

Effects of gepirone on ethanol consumption, exploratory behavior, and motor performance in rats

Contact Info

Product

Resources

About