The 460Trp allele of α-adducin increases carotid intima–media thickness in young adult males

Sarzani, Riccardo; Cusi, Daniele; Salvi, F.; Barlassina, Cristina; Macciardi, Fabìo; Pietrucci, Francesca; Cola, Giovanna; Catalini, R.; Fiume, Chiara Dal; Dessı̀-Fulgheri, Paolo; Rappelli, A

doi:10.1097/01.hjh.0000217852.89745.dc

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…12 In brief, we recruited YMs without previously diagnosed cardiovascular diseases. Family history of hypertension, smoking habits, and physical activity were carefully evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…In this context, lean YM carriers of the 129T allele might have higher EC levels and lower BP, whereas OH patients might have a further EC overactivity with unclear effects on BP. 6 This study aimed at investigating whether the FAAH P129T gene variant is associated with cardiovascular effects in YM participants of the Ancona Heart Doctor Study (AHDS) 12 and in an older population of male OH patients. To further study the possible effect of 129T FAAH variant in YMs, we also analyzed clinical parameters of a subset of YMs who underwent 9 years of follow-up.…”

Section: Faah Functional Variant and Bp In Young Malesmentioning

confidence: 99%

See 1 more Smart Citation

A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males

Sarzani

Bordicchia

Salvi

et al. 2008

American Journal of Hypertension

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“…12 In brief, we recruited YMs without previously diagnosed cardiovascular diseases. Family history of hypertension, smoking habits, and physical activity were carefully evaluated.…”

Section: Methodsmentioning

confidence: 99%

Section: Faah Functional Variant and Bp In Young Malesmentioning

confidence: 99%

A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males

Sarzani

Bordicchia

Salvi

et al. 2008

American Journal of Hypertension

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“…3 However, the 460Trp allele contributed substantially to the increased carotid intima media thickness in young, adult males. 4 In a study by Balkenstein et al, 5,6 a relationship was observed between the intima media thickness of the large muscular femoral artery and the ACE gene. This relationship is only seen in the presence of the a-adducin 460Trp allele, thus suggesting the presence of an epistatic interaction.…”

Section: Introductionmentioning

confidence: 97%

Functional alterations of mesenteric small resistance arteries in Milan hypertensive and normotensive rats

et al. 2009

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The Milan hypertensive rat strain (MHS) is a genetic strain in which cardiovascular phenotypes seem to be dependent, at least in part, on adducin gene polymorphisms. The aim of our study was to evaluate the structure, contractile responses and endothelium-dependent vasodilation in mesenteric small resistance arteries in 12-week-old MHS, (n¼7), age-matched Milan normotensive rats (MNS, n¼7) and congenic strains in which the DNA segments carrying the a-adducin locus from the MHS have been introgressed into the MNS (MNA, n¼7). Systolic blood pressure (tail cuff) and left ventricular weight to body weight were measured. Mesenteric small arteries were dissected and mounted on a micromyograph; the media:lumen ratio was then calculated. Concentration-response curves to acetylcholine and to norepinephrine (NE) were created. Systolic blood pressure was significantly increased in the MHS and MNA strains compared with the MNS. No significant difference in mesenteric small resistance artery structure was observed among the groups; however, a slightly more elevated media:lumen ratio was observed in MNA compared with the MNS. In contrast, left ventricular weight to body weight was significantly increased and ACH-induced dilatation was significantly impaired in the MHS and in MNA compared with MNS. The concentration-response curve to NE in the MHS showed significantly reduced sensitivity to NE; however, maximum contraction was increased in the MHS vs. the other groups. The MHS presents cardiac (but not vascular) remodeling, endothelial dysfunction and a peculiar contractile response to NE, compared with the other groups. The systolic blood pressure increase and trend to vascular remodeling in MNA support the pathogenic role of a-adducin.

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“…16 This genotyping of healthy subjects was performed in order to exclude the hypothesis that some variants might be present and/or more frequent specifically in patients with kidney cancer.…”

Section: Genotypingmentioning

confidence: 99%

Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue

et al. 2009

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Human angiotensinogen (AGT) gene promoter polymorphisms (GÀ217A; AÀ20C; GÀ6A) influence AGT transcription in vitro and have been implicated in the genetics of essential hypertension. We analysed the association among AGT promoter variants and AGT mRNA levels in human kidney and visceral adipose tissue (VAT) in vivo. Samples of kidney and VAT were obtained from 35 consecutive patients undergoing renal surgery. The AGT gene promoter of each patient was sequenced to identify variants. AGT gene expression was studied by real-time PCR TaqMan assay. Clinical data obtained before surgery were also considered in the statistical analysis. Two new polymorphisms at À175 and at À163 were identified. Although AGT expression was significantly higher in VAT than in the kidney, when both variants were present together AGT expression in VAT was about fivefold lower (P ¼ 0.033) than in the wild haplotype. This lower AGT expression in VAT suggests that the proximity and linkage of À175A and À163A variants might destabilize the binding of specific transcription factors to an acute-phase responsive element 3. Among the known AGT promoter variants, only À20C SNP has an important effect on tissue-specific differential AGT expression in the human tissues studied, inducing a 3.8-fold increase in AGT mRNA localized only in the kidney medulla (P ¼ 0.038). The other known polymorphisms (GÀ6A; GÀ217A) were not associated with different levels of AGT expression. Our results support the hypothesis that some human AGT promoter variants influence transcriptional activity in a tissue-specific way in humans.

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The 460Trp allele of α-adducin increases carotid intima–media thickness in young adult males

Abstract: The 460Trp allele of ADD1 contributes substantially to increase carotid IMT, in a male hormonal milieu only, at least in the young age range.

Cited by 11 publications

References 42 publications

A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males

A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males

Functional alterations of mesenteric small resistance arteries in Milan hypertensive and normotensive rats

Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue

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