The 40-Hz White Light-Emitting Diode (LED) Improves the Structure–Function of the Brain Mitochondrial KATP Channel and Respiratory Chain Activities in Amyloid Beta Toxicity

Nazari, Maryam; Vajed-Samiei, Taha; Torabi, Nihad; Fahanik-Babaei, Javad; Saghiri, Reza; Khodagholi, Fariba; Eliassi, Afsaneh

doi:10.1007/s12035-021-02681-7

Cited by 8 publications

(7 citation statements)

References 82 publications

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“…This age was chosen based on previous literature outlining the timing of adolescence in rodents. Postnatal day (PND [25][26][27][28][29][30] marks the beginning of early adolescence in male and female rats, while PND 60-70 marks the beginning of early adulthood 23,24 . Seventy-two pre-adolescent male and female Wistar rats from eight mothers were randomly assigned to the experimental or control groups.…”

Section: Methods and Materials Animalmentioning

confidence: 99%

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Efficacy of melatonin in alleviating disorders arising from repeated exposure to sevoflurane in males and females of the Wistar rats during preadolescence

Heydari,

Nasiri,

Haroabadi

et al. 2024

Sci Rep

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Pediatricians use sevoflurane due to its fast action and short recovery time. However, studies have shown that repeated exposure to anesthesia can affect learning and memory. Melatonin, an indole-type neuroendocrine hormone, has significant anti-inflammatory, and neuroprotective properties. Melatonin’s impact on cognitive behavior in sevoflurane-anesthetized males and females of the Wistar rats during preadolescence was examined in this research. The cognitive function was evaluated by shuttle box and morris water maze tests, while interleukin-10, Catalase (CAT), Malondialdehyde (MDA), and Tumor Necrosis Factor-α (TNF-α) were evaluated using ELISA kits. The expression levels of the apoptosis-linked proteins, Bax, Bcl-2, and caspase-3, were determined using the western blotting technique. The learning and memory latencies of the rats were more significant in the sevoflurane groups than in the control group; however, the latencies were significantly shorter in the sevoflurane and melatonin groups than in the control group. The levels of MDA, TNF-α, Bax, and caspase-3 were significantly higher in the sevoflurane groups than in the control group. We also found that the levels of CAT and Bcl-2 were significantly reduced in the sevoflurane groups compared to the control group. Increasing levels of CAT, Bcl-2, and decreasing levels of MDA, TNF-α, Bax, and caspase-3 in response to melatonin indicate a possible contribution to the recovery from the sevoflurane impairment. Melatonin shows neuroprotective effects in male and female rats with sevoflurane-induced cognitive impairment. This suggests melatonin could be a valuable treatment for learning and memory deficits resulting from repeated exposure to sevoflurane, possibly by controlling apoptosis, oxidative stress, and inflammation.

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Section: Methods and Materials Animalmentioning

confidence: 99%

“…The Western blot analysis was performed as previously described 27,28 . The tissue of hippocampus was lysed with RIPA buffer for western blotting.…”

Section: Apoptosis Measurement Through Western Blottingmentioning

confidence: 99%

Efficacy of melatonin in alleviating disorders arising from repeated exposure to sevoflurane in males and females of the Wistar rats during preadolescence

Heydari,

Nasiri,

Haroabadi

et al. 2024

Sci Rep

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“…Mitochondria were extracted as previously described ( Nazari et al, 2022 ). Briefly, rat brains were rapidly removed and minced in an isolation buffer (70 M sucrose, 230 mM mannitol, 1.0 mM EDTA, and 10 mM Tris–HCl, pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

Pre- and post-treatment of α-Tocopherol on cognitive, synaptic plasticity, and mitochondrial disorders of the hippocampus in icv-streptozotocin-induced sporadic Alzheimer’s-like disease in male Wistar rat

et al. 2023

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ObjectiveMost dementia cases in the elderly are caused by Alzheimer’s disease (AD), a complex, progressive neurological disease. Intracerebroventricular (ICV) administration of streptozotocin (STZ) in rat’s results in aberrant brain insulin signaling, oxidative stress, and mitochondrial dysfunction that impair cognition change neural plasticity, and eventually lead to neuronal death. The current study aims to define the neuroprotective action of alpha-tocopherol in enhancing mitochondrial function and the function of synapses in memory-impaired rats brought on by icv-STZ.MethodsMale Wistar rats were pre-treated with (α-Tocopherol 150 mg/kg) orally once daily for 7 days before and 14 days after being bilaterally injected with icv-STZ (3 mg/kg), while sham group rats received the same volume of STZ solvent. After 2 weeks of icv-STZ infusion, rats were tested for cognitive performance using a behaviors test and then were prepared electrophysiology recordings or sacrificed for biochemical and histopathological assays.ResultsThe cognitive impairment was significantly minimized in the behavioral paradigms for those who had taken α-Tocopherol. In the hippocampus of icv-STZ rat brains, α-Tocopherol ocopherol effectively prevented the loss of glutathione levels and superoxide dismutase enzyme activity, lowered mitochondrial ROS and mitochondrial membrane potential, and also brought about a decrease in Aβ aggregation and neuronal death.ConclusionOur findings demonstrated that by lowering neurobehavioral impairments caused by icv-STZ, oxidative stress, and mitochondrial dysfunction, α-Tocopherol enhanced intracellular calcium homeostasis and corrected neurodegenerative defects in the brain. These findings examine the available approach for delaying AD connected to mitochondrial malfunction and plasticity issues.

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“…In addition, the 40-Hz white light-emitting diode boosted the activity of brain mitochondrial ATP-sensitive potassium channel, as well as the structural and functional couplings of respiratory chain activity, enhancing mitochondrial function and neuroplasticity (Nazari et al, 2022).…”

Section: Light Stimulationmentioning

confidence: 99%

“…Forty‐hertz flicker leads to specific neuroimmune responses by upregulating the phosphorylation of proteins in the nuclear factor κ ‐light‐chain‐enhancer of activated B cells and mitogen‐activated protein kinase pathways to increase an expression of cytokines (Garza et al, 2020 ). In addition, the 40‐Hz white light‐emitting diode boosted the activity of brain mitochondrial ATP‐sensitive potassium channel, as well as the structural and functional couplings of respiratory chain activity, enhancing mitochondrial function and neuroplasticity (Nazari et al, 2022 ).…”

Section: Basic Principles and Mechanisms Of Audiovisual Stimulationmentioning

confidence: 99%

Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function

Chen

Shi

et al. 2022

Brain and Behavior

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Background: Audiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non-invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as cognitive, language, motor, mood, and sleep dysfunctions. However, the exact mechanism underlying the therapeutic effect of 40-Hz audiovisual stimulation remains unclear; the clinical applications of 40-Hz audiovisual stimulation in brain dysfunctions rehabilitation still need further research.Objective: In order to provide new insights into brain dysfunction rehabilitation, this review begins with a discussion of the mechanism underlying 40-Hz audiovisual stimulation, followed by a brief evaluation of its clinical application in the rehabilitation of brain dysfunctions.Results: Currently, 40-Hz audiovisual stimulation was demonstrated to affect synaptic plasticity and modify the connection status of related brain networks in animal experiments and clinical trials. Although its promising efficacy has been shown in the treatment of cognitive, mood, and sleep impairment, research studies into its application in language and motor dysfunctions are still ongoing. Conclusions:Although 40-Hz audiovisual stimulation seems to be effective in treating cognitive, mood, and sleep disorders, its role in language and motor dysfunctions has yet to be determined.

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The 40-Hz White Light-Emitting Diode (LED) Improves the Structure–Function of the Brain Mitochondrial KATP Channel and Respiratory Chain Activities in Amyloid Beta Toxicity

Cited by 8 publications

References 82 publications

Efficacy of melatonin in alleviating disorders arising from repeated exposure to sevoflurane in males and females of the Wistar rats during preadolescence

Efficacy of melatonin in alleviating disorders arising from repeated exposure to sevoflurane in males and females of the Wistar rats during preadolescence

Pre- and post-treatment of α-Tocopherol on cognitive, synaptic plasticity, and mitochondrial disorders of the hippocampus in icv-streptozotocin-induced sporadic Alzheimer’s-like disease in male Wistar rat

Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function

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