The 40-Hz Auditory Steady-State Response in Patients With Schizophrenia

Thuné, Hanna; Recasens, Marc; Uhlhaas, Peter J.

doi:10.1001/jamapsychiatry.2016.2619

Cited by 237 publications

(257 citation statements)

References 69 publications

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“…This is an important finding, given the increasing use of the ASSR as a biomarker in investigations of neuropsychiatric disorders (O’Donnell et al, 2013; Sivarao et al, 2016; Thune et al, 2016). Consistent with our previous findings with EEG data (McFadden et al, 2014), we found the ASSR to be reliable across two sessions, spaced approximately one week apart.…”

Section: Discussionmentioning

confidence: 78%

“…Although it is more common to measure in sensor space in the EEG literature, certain ERP measures also appear to benefit from source-analysis related improvement in signal-to-noise ratio and test-retest reliability (e.g., see Segalowitz et al, 2010). As much of the literature involving the use of the ASSR as a biomarker in studies of neuropsychiatric disorders uses source-space projected data, at least when the imaging technique is MEG (e.g., see meta-analysis of EEG and MEG ASSR from Thune et al, 2016), we felt it would be more applicable to assess reliability of this measure.…”

Section: Discussionmentioning

confidence: 99%

“…40 Hz amplitude-modulated stimuli (e.g., amplitude-modulated tones, white noise, or click trains) can be used to entrain the ASSR, which peaks around 40 Hz in humans (Azzena et al, 1995; Hari et al, 1989) and can be measured using electroencephalography (EEG) or magnetoencephalography (MEG). ASSR abnormalities have been observed in autism spectrum disorders (Wilson et al, 2007), schizophrenia (Brenner et al 2003; Hayrynen et al, 2016; Kwon et al, 1999; Light et al, 2006; O’Donnell et al, 2013; Roach et al, 2013; Spencer et al, 2008; Thune et al, 2016), and bipolar disorder (Isomura et al, 2016; Maharajh et al, 2007; O’Donnell et al, 2004; Oda et al, 2012; Rass et al, 2010). Heritability of these abnormalities has been suggested, as they have also been identified in first-degree relatives of individuals with autism (Rojas et al, 2011) and schizophrenia (Hong et al, 2004; Rass et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…However, there is also evidence suggesting that the ASSR involves glutamatergic dysfunction (Brenner et al, 2009; Kwon et al, 1999; Leishman et al, 2015; O’Donnell et al, 2013; Plourde et al, 1997; Sivarao et al, 2013; Sivarao, 2015; Sivarao et al, 2016; Vohs et al, 2012), particularly supported by emerging evidence that the 40 Hz ASSR may be more sensitive to N -methyl-D-aspartate (NMDA) receptor antagonism than to GABA-A receptor antagonism (Sullivan et al, 2015). With this growing body of evidence, the ASSR demonstrates strong potential as a biomarker in clinical studies of neuropsychiatric disorders (O’Donnell et al, 2013; Sivarao, 2015; Thune et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

Legget

Hild

Steinmetz

et al. 2017

International Journal of Psychophysiology

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The auditory steady-state response (ASSR) is increasingly being used as a biomarker in neuropsychiatric disorders, but research investigating the test-retest reliability of this measure is needed. We previously reported ASSR reliability, measured by electroencephalography (EEG), to 40 Hz amplitude-modulated white noise and click train stimuli. The purpose of the current study was to (a) assess the reliability of the MEG-measured ASSR to 40 Hz amplitude-modulated white noise and click train stimuli, and (b) compare test-retest reliability between MEG and EEG measures of ASSR, which has not previously been investigated. Additionally, impact of stimulus parameter choice on reliability was assessed, by comparing responses to white noise and click train stimuli. Test-retest reliability, across sessions approximately one week apart, was assessed in 17 healthy adults. On each study day, participants completed two passive listening tasks (white noise and click train stimuli) during separate MEG and EEG recordings. Between-session correlations for evoked power and inter-trial phase coherence (ITPC) were assessed following source-space projection. Overall, the MEG-measured ASSR was significantly correlated between sessions (p < 0.05, FDR corrected), suggesting acceptable test-retest reliability. Results suggest greater response reproducibility for ITPC compared to evoked responses and for click train compared to white noise stimuli, although further study is warranted. No significant differences in reliability were observed between MEG and EEG measures, suggesting they are similarly reliable. This work supports use of the ASSR as a biomarker in clinical interventions with repeated measures.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

Legget

Hild

Steinmetz

et al. 2017

International Journal of Psychophysiology

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“…Until recently, the large body of work implicating abnormal gamma band activity in ScZ has focused on rhythmic activity in the 40-Hz frequency range with EEG. The most consistent evidence from these studies is a reduction in both amplitude and phase locking of 40-Hz auditory steady-state responses (39, 40). …”

Section: Meg Studies In Neuropsychiatric Disordersmentioning

confidence: 78%

Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective

Uhlhaas

Liddle

Linden

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. We propose that recent technological and analytic advances in magnetoencephalography (MEG), a technique that allows measurement of neuronal events directly and noninvasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as schizophrenia, autism spectrum disorders, and the dementias. We summarize the mechanisms underlying the generation of MEG signals and the tools available to reconstruct generators and underlying networks using advanced source-reconstruction techniques. We then surveyed recent studies that have used MEG to examine aberrant rhythmic activity in neuropsychiatric disorders. This was followed by links with preclinical research that has highlighted possible neurobiological mechanisms, such as disturbances in excitation/inhibition parameters, that could account for measured changes in neural oscillations. Finally, we discuss challenges as well as novel methodological developments that could pave the way for widespread application of MEG in translational research with the aim of developing biomarkers for early detection and diagnosis.

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Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Pellegrino

Arcara

Pino

et al. 2019

Human Brain Mapping

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Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham‐controlled, double‐blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory‐motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro‐temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

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The 40-Hz Auditory Steady-State Response in Patients With Schizophrenia

Cited by 237 publications

References 69 publications

MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective

Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

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