The −374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes

Santos, Kátia Gonçalves dos; Canani, Luís Henrique Santos; Gross, Jorge Luiz; Tschiedel, Balduíno; Souto, Kátia Elisabete Pires; Roisenberg, Israel

doi:10.1016/j.ymgme.2005.02.010

Cited by 57 publications

(57 citation statements)

References 24 publications

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“…For the -374A allele (26.0%, 95%CI = 21-31%) the frequencies observed in the GDM group were similar to those reported for Euro-and Afro-Brazilians with type 2 diabetes (31-24%; Dos Santos et al, 2005) and for other Caucasian populations (NCBI, 2009).…”

Section: Discussionsupporting

confidence: 82%

“…The frequencies of the rare -429C allele (6.3%, 95%CI = 4-9%) observed for the GDM group were lower than those reported for Euro-and Afro-Brazilians with type 2 diabetes (12%; Dos Santos et al, 2005) or Brazilians with type 1 diabetes (19.1%; Picheth et al, 2007). On the other hand, these frequencies are similar to those reported for healthy Brazilian subjects (10%; Picheth et al, 2007).…”

Section: Discussioncontrasting

confidence: 37%

“…The -429C allele was associated with type 1 diabetes (Picheth et al, 2007) and to diabetic retinopathy (Hudson et al, 2001a), while other studies showed no association of this allele with diabetes (Dos Santos et al, 2005;Kankova et al, 2005).…”

Section: Discussionmentioning

confidence: 84%

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Short Communication The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

Santos¹,

Daga²,

Frigeri³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have proinflammatory actions in human gestational tissues, increasing oxidative stress and the release of cytokines and prostaglandins. We RAGE SNPs and gestational diabetes investigated the association of RAGE gene promoter polymorphisms -429T>C (rs1800625) and -374T>A (rs1800624) with gestational diabetes. A sample of 750 unrelated European origin pregnant Brazilian women were classified as nondiabetic (control group, N = 600) or having gestational diabetes (N = 150) according to American Diabetes Association 2009 criteria. Genotyping was performed by PCR-RFLP. The frequencies of the rare alleles -429C (6.3 versus 9.1%) and -374A (26 versus 30%) were not significantly different between the gestational diabetes patients and healthy pregnant women. Also, the -429T>C and -374T>A polymorphisms were not associated with body mass index, lipid profile, fasting glycemia, HbA1C, or insulin requirement. We found that functional promoter polymorphisms of the RAGE gene were not associated with gestational diabetes or its complications in these Euro-Brazilian patients.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 37%

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Short Communication The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

Santos¹,

Daga²,

Frigeri³

et al. 2010

Genet. Mol. Res.

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“…Interestingly, Pettersson-Fernholm et al [18] found an association between the −374 T/A polymorphism and diabetic nephropathy in Finnish type 1 diabetic patients with high HbA 1c [18]. They also showed a significant association between the AGER −374 T/A polymorphism and macrovascular disease; a similar association with cardiovascular disease had previously been demonstrated both in type 2 diabetic patients and in nondiabetic subjects [19][20][21]. Patients homozygous for the minor allele (A/A) had a reduced risk for cardiovascular disease.…”

mentioning

confidence: 64%

“…Similarly, studies on macrovascular disease in type 2 diabetic and in non-diabetic patients [19][20][21] have shown a protective role of the A allele. However, several other studies support the role of A allele as a risk factor rather than a protective factor against diabetic complications.…”

Section: Discussionmentioning

confidence: 90%

The −374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients

et al. 2006

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Aims/hypothesis The receptor for AGE (RAGE) is considered to be mainly an intracellular signal-transducer or pro-inflammatory peptide of possible importance for inflammation and autoimmune diseases. Our aim was to study whether the −374 T/A polymorphism in the gene encoding RAGE (AGER) is associated with diabetes type and presence of diabetic complications. Methods The AGER −374 T/A polymorphism was genotyped in 867 type 1 diabetic patients, 2,467 type 2 diabetic patients and 205 non-diabetic control subjects of Scandinavian origin. Results AGER polymorphism was related to different HLA-DQB1 genotypes and the presence of diabetic complications. Type 1 diabetic patients had a higher frequency of the AGER −374 A/A or T/A genotypes than type 2 diabetic patients (51.1 vs 44.9%, p=0.002) and control subjects (51.1 vs 47.6%, p=0.0006). The RAGE −374 T/A polymorphism was associated with HLA-DQB1 genotypes; patients with HLA risk genotypes had a higher frequency of the A/A or T/A genotypes than patients with other HLA-DQB1 genotypes (60.3 vs 40.3%, p<0.000001). In type 1 diabetic patients, the frequency of the A/A or T/A genotypes was higher in patients with diabetic nephropathy than without (61.1 vs 46.8%, p=0.006) and with sightthreatening retinopathy than without (56.1 vs 47.6%, p=0.03). In type 2 diabetic patients with HbA 1c values below the median, the T/T genotype was more frequent in patients with diabetic nephropathy than without (54.3 vs 38.2%, p=0.02). Conclusions/interpretation Our results show an association between the AGER −374 T/A polymorphism and type 1 diabetes. This association was HLA-DQB1-dependent. The polymorphism was associated with diabetic nephropathy in both type 1 and type 2 diabetes, in an HbA 1c -dependent manner in the latter group, and also with sight-threatening retinopathy in type 1 diabetic patients.

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Rheumatoide Arthritis: Zusammenhänge zwischen kardiovaskulären Erkrankungen und dem "Advanced Glycation End Product Receptor"

Carroll

Hannawi

Marwick

et al. 2006

Wien Med Wochenschr

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Cardiovascular (CV) disease is increased in patients with chronic inflammatory disease, including rheumatoid arthritis (RA). Furthermore it has become clear at a pathophysiological level, that atherosclerosis has striking similarities with autoimmune disease. This realization has come at a time of paradigm shift in how rheumatologists manage RA, with the availability of biological agents targeting key inflammatory cytokines. This review will focus on the possible causes of increased vascular disease in RA, including the role of traditional CV risk factors. Mechanisms potentially at play, such as C-reactive protein (CRP), altered coagulation, and cyclooxygenase (COX)-2 inhibitors will be covered in brief. The receptor for advanced glycation end products (RAGE) has been identified as a candidate molecule influencing response to ongoing inflammation and autoimmunity. There will be a focus on the role of RAGE in CV disease and RA. As has been the case with many novel molecules, functional polymorphisms are thought to alter disease expression and assist us in coming to terms with the biological activities of the parent molecule. The review will conclude with a discussion of the potential role of the RAGE Glycine 82 Serine polymorphism.

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The −374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes

Cited by 57 publications

References 24 publications

Short Communication The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

Short Communication The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

The −374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients

Rheumatoide Arthritis: Zusammenhänge zwischen kardiovaskulären Erkrankungen und dem "Advanced Glycation End Product Receptor"

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