2007
DOI: 10.1515/cclm.2007.273
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The −374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients

Abstract: This result confirms that the -374AA genotype of the RAGE gene promoter is a protective factor against the severity of CAD lesions in type 2 diabetic patients.

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Cited by 28 publications
(18 citation statements)
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“…The close connection between these polymorphic -429C and 2184G alleles has to be pointed out and the same is true for the 2184GG genotype, which it is connected with higher sRAGE and esRAGE levels as well [20] . Concerning cardiovascular risk, the A allele of the -374T/A polymorphism, which was also examined in our study, was associated with a decreased risk for cardiovascular disease in the general population or in diabetic patients [15,17,18,[23][24][25] . The Gly82Ser polymorphism was not associated with cardiovascular disease in the Framingham offspring study [26] as well as in patients with rheumatoid arthritis [27] .…”
mentioning
confidence: 51%
“…The close connection between these polymorphic -429C and 2184G alleles has to be pointed out and the same is true for the 2184GG genotype, which it is connected with higher sRAGE and esRAGE levels as well [20] . Concerning cardiovascular risk, the A allele of the -374T/A polymorphism, which was also examined in our study, was associated with a decreased risk for cardiovascular disease in the general population or in diabetic patients [15,17,18,[23][24][25] . The Gly82Ser polymorphism was not associated with cardiovascular disease in the Framingham offspring study [26] as well as in patients with rheumatoid arthritis [27] .…”
mentioning
confidence: 51%
“…The functional single nucleotide polymorphisms (SNPs), including variation I codon 82 (G82S, rs 2070600), resulting from the amino acid exchange of glycine for serine in domain V and two polymorphic regions in the promoting region, -429T>C (rs 1800625) and -374T>A (rs 1800624), have been extensively researched in association with pathologies (25) . The allele 374A of RAGE promoter has been associated as a protector against macrovascular damage in patients with DM type 2 (44,55) and the allele -429C with diabetes type 1 (DM1) (56) . More recently, the genome-wide association studies (GWAS) has shown the association of polymorphism G82S with pulmonary function (22) .…”
Section: Rage Gene Structure and Organizationmentioning
confidence: 99%
“…Interestingly, case/controls studies have revealed a strong link between an individual's possession of the − 374A allele or AA genotype and protection against vascular disease. These include decreased risk of cardio-and cerebral-vascular disease [106][107][108][109], a decrease in restenosis after angioplasty [110], the number of affected vessels [111,112], and mortality after myocardial infarction (Table 2) [113]. Studies have not identified an association with diabetic retinopathy [92,[114][115][116], which is not surprising since genetic studies of diabetic microvascular complications did not reveal a genetic component on the pathogenesis of retinopathy.…”
Section: Promoter Region Variants Of the Rage Gene: − 374t > Amentioning
confidence: 99%