The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2.

Passini, Nadia; Larigan, J D; Genovese, Stefano; Appella, Ettore; Sinigaglia, Francesco; Rogge, Lars

doi:10.1073/pnas.92.20.9412

Cited by 66 publications

(49 citation statements)

References 21 publications

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“…It is synthesised as a M r 105 000 core protein, which undergoes glycation resulting in a mobility corresponding to M r 120 000 on SDS-gels [6,8,31]. The carbohydrate moiety in glima 38 does not, however, seem to contribute to the autoreactive epitopes in the molecule [7].…”

Section: Discussionmentioning

confidence: 99%

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients

et al. 2000

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“…Antibodies to glutamic acid decarboxylase (GAD)/64 kDa protein have also been detected in diabetic and non-diabetic endocrine patients (7)(8)(9)(10). More recently, the predictive value of 37/40 kDa antibodies, identified as IA2 and phogrin proteins (11)(12)(13)(14)(15), has been reported in nondiabetic patients with organ-specific autoimmune disease (16). Very few of these studies previously published on anti-pancreatic immunity in Caucasian endocrine patients, were homogeneous with regard to the initial disease and the intensity of extra-pancreatic autoimmunity at the time of sampling and studied the whole range of humoral markers available.…”

Section: Introductionmentioning

confidence: 98%

“…Antibodies to 37/40 kDa which recognize tyrosine phosphatase proteins IA2 and phogrin (11)(12)(13)(14)(15) were only detected in 4 of the 150 tested patients. These 4 positive patients also displayed ICA and 3 of them GAD/ 64 kDa antibodies.…”

Section: Journal Of Endocrinology (1997) 137mentioning

confidence: 99%

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients

Maugendre¹,

Verite²,

Guilhem³

et al. 1997

European Journal of Endocrinology

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The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among subjects at risk of diabetes.Ten were already diabetic at GD diagnosis. Among the 590 non-diabetic patients, 29 had islet cell antibodies (ICA), including 15 with low titre ICA and only 1 ICA-positive subject with a familial history of diabetes. Twenty-four patients had insulin autoantibodies, including three in association with ICA. Glutamic acid decarboxylase (GAD)/64 kDa antibodies were found in 16 of the 150 tested sera, including 13 of the 29 ICA-positive sera. Four ICA-positive patients displayed 37/40 kDa antibodies, including three in association with GAD/64 kDa antibodies. During follow-up, one of the ICA-positive patients developed insulin-dependent diabetes, 14 years after the GD diagnosis.To summarize, this anti-pancreatic autoimmunity study was focused on a large but specific and homogeneous group of subjects at risk for diabetes: recently diagnosed GD patients. This population was characterized by a high prevalence of GAD/64 kDa antibodies but also by a low frequency of evolution towards diabetes and the slowness of the process which could be due to the fact that only a minority of subjects possessed a sufficient combination of anti-pancreatic markers at the same time.

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“…The 40 and 37 kDaantigens have been identified as two closely related proteins designated IA-2 (or ICA512) and phogrin (or IA-2fl), respectively [6][7][8][9][10]. Autoantibodies to both IA-2 and phogrin bind epitopes that are restricted to the cytoplasmic domain of these proteins [10][11][12].…”

mentioning

confidence: 99%

Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM

et al. 1997

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The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2.

Abstract: Major targets for autoantibodies associated with the development of insulin-dependent diabetes mellitus (IDDM) include tryptic fragments with a molecular mass of 37 kDa and/or 40

Cited by 66 publications

References 21 publications

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients

Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM

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