The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women

Abstract

This study explored interactions between dietary fat intake and the tumour necrosis factor-a gene (TNFA) -308 G/A polymorphism on serum lipids in white South African (SA) women. Normal-weight (N = 88) and obese (N = 60) white SA women underwent measurements of body composition, fat distribution, fasting serum lipids, glucose, insulin concentrations and dietary intake. Subjects were genotyped for the functional -308 G/A polymorphism within the TNFA gene. There were no significant differences in the genotype or allele frequencies between groups, and no significant genotype associations were found for body fatness or distribution, or serum lipid concentrations. However, there was a significant interaction effect between dietary saturated fat (SFA) intake (%E) and TNFA -308 genotypes on serum total cholesterol concentrations (P = 0.047). With increasing SFA intake (%E), serum total cholesterol levels decreased for the GG genotype and increased for the GA plus AA genotypes. The TNFA -308 G/A polymorphism appears to modify the relationship between dietary fat intake and serum total cholesterol concentrations in white SA women.

Interleukin-6 Gene Polymorphisms, Dietary Fat Intake, Obesity and Serum Lipid Concentrations in Black and White South African Women

“…For the IL-6 −174 G>C, IVS3 +281 G>T, and IVS4 +869 A>G polymorphisms reported here it appears that the minor alleles of these polymorphisms may be more responsive to the quantity and quality of the dietary fat being consumed, compared to the major allele. Similar results have been observed for the TNFA polymorphisms, where the minor A allele was more responsive to changes in dietary fat intake [17,18]. Notably, in this study the individual diet-gene interactions differed between the two ethnic groups.…”

Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non-diabetic women: a case for metabolic flexibility?

“…A convenience sample of 180 healthy premenopausal urban-dwelling white South African women between the ages of 18 to 45 years was recruited through the local media, as part of a larger study [24]. The protocol was approved by the Research Ethics Committee of the Faculty of Health Sciences, University of Cape Town.…”

The dietary monounsaturated to saturated fatty acid ratio modulates the genetic effects of GCKR on serum lipid levels in children

“…Blood lipid levels are influenced by genetic and environmental factors, including the intake and interactions of dietary fatty acids, in almost all ethnic groups [3], [4], [5] and [6].…”