The 3’-UTR Polymorphisms in the NLRP3 Gene Associated with the Risk of COPD and Their Putative Effects on the microRNA Mechanism
Wu Hui Yan,
Huang Chu Ting,
Zhang Yan Ling
et al.
Abstract:Objective Evaluating the association between a single nucleotide polymorphism in the 3'UTR region of the miRNAs binding site of the NLRP3 gene and the occurrence and development of Chronic Obstructive Pulmonary Disease (COPD) and providing information to aid in the early detection and treatment of COPD.
Methods The regulatory SNPs located in NLRP3 3'UTR region were searched by using dbSNP database and miRNA binding site prediction database. Meanwhile, samples from COPD patients and healthy controls in the sam… Show more
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