The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients

Abstract

The NFKBIA 3'UTR GG genotype was associated with an increased risk for extensive colitis in Hungarian patients. In contrast, variant alleles did not predict response to medical therapy or need for surgery.

Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

“…The NFKBIA gene is located on chromosome 14q13 and has six exons spanning 3.5 kb. Polymorphisms have been discovered in the NFKBIA gene, and many studies have been conducted to test the association of these polymorphisms with autoimmune and inflammatory diseases, but the association trends observed have been variable; some studies show an association while others do not [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. It is necessary to perform a comprehensive meta-analysis to assess the importance of NFKBIA gene polymorphisms for autoimmune and inflammatory diseases susceptibility.…”

“…Characteristics of studies investigating the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases are presented in Table 1 [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. There were 41 papers relevant to the search terms.…”

“…There were 41 papers relevant to the search terms. Through the step of screening the abstract, 27 of these articles were excluded (two were review; four weren't case-control study; three didn't explore NFKBIA gene polymorphism; 18 didn't explore autoimmune and inflammatory diseases), leaving 14 studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27] for full publication review. Of these, the frequencies of alleles and genotypes of three studies were unavailable [15,18,19].…”

“…Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (5 studies [14,16,17,20,21] [22,[24][25][26][27]). Eight separate studies were used in the current meta-analysis [14,16,17,[20][21][22][24][25][26][27].…”

“…Eight separate studies were used in the current meta-analysis [14,16,17,[20][21][22][24][25][26][27]. The distribution of the genotype in control population was in Hardy-Weinberg equilibrium in eligible studies (P [ 0.05).…”