The −295T-to-C promoter polymorphism of the IL-16 gene is associated with crohn’s disease

Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene

“…The distribution of IL16 -295 genotypes in the healthy control group without eczema (n = 310, Table I) was in Hardy-Weinberg equilibrium and could be confirmed in a second independent group of healthy individuals (n = 214, Table II). IL16 -295 genotype frequencies in this group were different, however, compared with those reported in an earlier German study 29 (explorative exact P from χ 2 test of independence = .037). This earlier study included patients with inflammatory bowel disease (n = 203) and healthy subjects (n = 120) but did not contain information on sex, ethnical background, and precise inclusion criteria.…”

“…17 One major difference between AD and ACD regarding the cutaneous cytokine milieu is that T H 2-type cytokines dominate in AD, at least in acute lesions, whereas ACD is thought to be driven by T H 1-type cytokines. Therefore the observed association between the IL16 -295 polymorphism and ACD and the lack of association in AD together with previous findings in Crohn's disease, 29 another T H 1-type inflammatory process, might point to a more prominent role of IL-16 in classical T H 1-type diseases.…”

Association of asthma with a functional promoter polymorphism in the IL16 gene

“…In 2002, Glas et al 26 reported an association between the IL16 2295 SNP and Crohn's disease. Subjects with Crohn's disease had significantly higher T-allele and TT-genotype frequencies compared with those seen in control subjects (P < .01).…”

Whipple's Disease: a Macrophage Disease

“…Finally, serum IL-16 levels are associated with the activity of the disease: they were higher in patients than in controls, and as soon as a successful treatment was administrated, IL-16 levels decreased to control values (19). Thus, WD may be added to the list of diseases in which IL-16 is involved, such as inflammatory bowel diseases (36,45,60,82,110).…”