The 21st UK Renal Registry Annual Report: A Summary of Analyses of Paediatric Data in 2017

Plumb, Lucy; Casula, Anna; Pyart, Rhodri; Evans, Katharine; Inward, Carol; Mu, James; Marks, Stephen D.

doi:10.1159/000504852

Cited by 19 publications

(11 citation statements)

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“…Incidence rates of kidney failure in our study cohort were relatively high compared with rates reported in Europe (an incidence of 7.8 pmarp in children up to 19 years in 2013–2018 according to the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) 17 versus 9.4 pmarp in the same years in our study and 10.2–7.9 pmarp in children up to 16 years in 2012–2017 in the United Kingdom 18 versus 9.2 pmarp in the same years in our study) but lower than the overall incidence rate reported in the United States (11 pmarp in children up to 17 years in 2019 versus 9.6 in the same year in our study). 19 Regarding ethnical variability, the highest incidence in the United States is reported among Black children and is still lower than the incidence among Israeli minorities (15.7 pmarp in Black children in the United States in 2017–2019 versus 18.6 and 21.1 pmarp among Arab and Druze children in the same years in our study).…”

Section: Discussioncontrasting

confidence: 54%

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Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons

Regev-Epstein

Frishberg

Davidovits

et al. 2023

CJASN

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Background Childhood kidney failure is a rare condition with worldwide clinical variability. We used a nationwide multicenter analysis to study the pretransplant course of the entire Israeli pediatric kidney failure population over 30 years.Methods In this nationwide, population-based, historical cohort study, we analyzed medical and demographic data of all children treated with KRT and reported to the Israeli kidney failure registry in 1990-2020. Statistical analysis was performed with incidence rate corrected for age, ethnicity, and calendar year, using the appropriate age-related general population as denominator. ResultsDuring the last 30 years, childhood incidence of kidney failure decreased. Average incidence in 2015-2019 was 9.1 cases per million age-related population (pmarp). Arab and Druze children exhibited higher kidney failure incidence rates than Jewish children (18.4 versus 7.0 cases pmarp for minorities versus Jews). The most common kidney failure etiologies among Arab and Jewish children were congenital anomalies of the kidney and urinary tract (approximately 27%), followed by cystic kidney diseases among Arab children (13%) and glomerulonephritis among Jewish children (16%). The most common etiology among Druze children was primary hyperoxaluria type 1 (33%). Israel's national health insurance provides access to primary health care to all citizens. Accordingly, waiting time for deceased-donor transplantation was equal between all ethnicities. Living-donor kidney transplantation rates among minority populations remained low in comparison with Jews over the entire study period. Although all patient groups demonstrated improvement in survival, overall survival rates were mainly etiology dependent.Conclusions In Israel, Arab and Druze children had a higher incidence of kidney failure, a unique etiological distribution, and a lower rate of living-donor kidney transplantations compared with Jewish children.

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Section: Discussioncontrasting

confidence: 54%

“…17 Worst survival among infants, as was seen in Israel, was also reported in the United Kingdom and the United States. 18,19…”

Section: Discussionmentioning

confidence: 99%

Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons

Regev-Epstein

Frishberg

Davidovits

et al. 2023

CJASN

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“…Even throughout Europe, inequalities exist and are contributed by the difference of country's macroeconomics 11 . The United Kingdom and the United States reported comparable incidence of 7.9–10.2 and 11.5 pmarp 12,13 . Interestingly, the reported incidence in Japan was much lower than other high‐income countries at 4 pmarp 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Whereas the incidence fluctuated considerably from year to year due to small absolute case number, an increasing incidence of ESKD receiving KRT was observed over the past two decades. In contrast, such rates remained relatively stable among Australia, Japan, United States, United Kingdom and European countries 5,11–14 . In Hong Kong, the public health care system, Hospital Authority, provides KRT with almost full subsidy and care for over 90% of patients with ESKD 6 .…”

Section: Discussionmentioning

confidence: 99%

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Demographics and long‐term outcomes of children with end‐stage kidney disease: A 20‐year territory‐wide study

Chan¹,

Yap

Wong

et al. 2021

Nephrology

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Aim To evaluate the demographics and long‐term patient outcomes of children with end‐stage kidney disease in Hong Kong. Methods We conducted a cohort study at the Paediatric Nephrology Centre, the designated site providing kidney replacement therapy (KRT) for children in Hong Kong. The clinical characteristics and outcomes of all children who initiated chronic KRT before 19 years, between 2001 and 2020, were analysed. Results One hundred forty‐seven children (50% male) received KRT at a mean age of 11.4 ± 5.7 years. The incidence of ESKD was 6.28 per million age‐related population (pmarp). The leading cause of ESKD was congenital anomalies (33%). Ten children (7%) had pre‐emptive kidney transplants, 104 (71%) and 33 (22%) patients received automated peritoneal dialysis and haemodialysis as initial KRT. The incidence of ESKD increased over time, and were 4.38, 5.07, 6.15 and 9.17 pmarp during 2001–2005, 2006–2010, 2011–2015 and 2016–2020, respectively (p = .005). Ninty‐seven patients (66%) received kidney transplants and the median time to receive a kidney graft was 3.7 years (95% CI 3.1–4.3). Only 10 patients had pre‐emptive kidney transplants. The mortality rate was 9.1 deaths per 1000‐patient‐years (95%CI 4.6–16.2). The survival probabilities at 1‐, 5‐, 10‐ and 15‐year were 100%, 94.8% (95%CI 90.7–98.9%), 89.7% (95% CI 83.4%–95.9%), 87.1% (95% CI 79.3%–94.9%), respectively. Standardised mortality ratio was 54.5. 72% of deaths were due to infections. Young infants and those without kidney transplants were associated with worse survival (p < .01). Multivariate analysis demonstrated that dialysis was the only factor associated with significantly increased risk of death (HRadj 12.9, 95% CI 2.7–63.2, p = .002). Conclusion We observed an increasing incidence of paediatric ESKD in Hong Kong with considerable waiting time to kidney transplant. Mortality risk is comparable to other developed countries and is highest among dialysis population. Efforts should be made to facilitate early access to paediatric kidney transplantation in Hong Kong.

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Protein restriction for diabetic kidney disease

Jiang

Fang

2023

Cochrane Database of Systematic Reviews

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The 21st UK Renal Registry Annual Report: A Summary of Analyses of Paediatric Data in 2017

Cited by 19 publications

References 0 publications

Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons

Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons

Demographics and long‐term outcomes of children with end‐stage kidney disease: A 20‐year territory‐wide study

Protein restriction for diabetic kidney disease

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