“…1,2 Characteristics of patients with CP/CPPS include a high prevalence, frequent recurrences, and a substantially impaired quality of life; [3][4][5][6] however, the etiology, pathogenesis, and optimal treatment of CP/CPPS remain unknown. Previous reports suggested that trigger factors of the chronic pelvic pain process could be infections, chemical irritation, trauma, genetics, and psychological stress that result in subsequent neurological changes, such as brain microstructural changes, central sensitization, and pelvic floor spasms.…”