2004
DOI: 10.1016/j.ibmb.2003.09.003
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The 20-hydroxyecdysone-induced cellular arrest in G2 phase is preceded by an inhibition of cyclin expression

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Cited by 24 publications
(33 citation statements)
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“…In D. melanogaster, pulses of 20E throughout fly development have proved to regulate cell proliferation, differentiation, and programmed cell death in a highly controlled manner. During metamorphosis, for example, ecdysone is a primary regulator of apoptosis in larval tissues such as salivary glands, midgut and neural tissues which are destroyed or remodelled into an "adult" form (Mottier et al, 2004;Tsuzuki et al, 2001). The activation and execution of ecdysis (i.e.…”
Section: Ecdysteroids: a Role As Sex Hormones In Insects?mentioning
confidence: 99%
“…In D. melanogaster, pulses of 20E throughout fly development have proved to regulate cell proliferation, differentiation, and programmed cell death in a highly controlled manner. During metamorphosis, for example, ecdysone is a primary regulator of apoptosis in larval tissues such as salivary glands, midgut and neural tissues which are destroyed or remodelled into an "adult" form (Mottier et al, 2004;Tsuzuki et al, 2001). The activation and execution of ecdysis (i.e.…”
Section: Ecdysteroids: a Role As Sex Hormones In Insects?mentioning
confidence: 99%
“…In arthropods, ecdysteroids can either stimulate cell proliferation or initiate cell differentiation [94][95][96] depending on the level of moulting hormones. This is accompanied by an arrest either at G2 [95,97,98] or at G1/S [99]. Periodic expression of EcR and Usp during the cell cycle and their impact on regulation of cell proliferation was reported recently [100][101][102].…”
Section: Ecdysteroids and Cell Cyclementioning
confidence: 99%
“…It was also demonstrated that in B. mori, ecdysteroids inhibit corpus allatum cell DNA synthesis (Gu and Chow, 2003a). Recently Mottier et al (2004) reported that the decrease in cyclin expression is related to 20-hydroxyecdysone-induced inhibition of the IAL-PID2 cell line established from imaginal wing discs of Plodia interpunctella. Further study is needed to clarify the role of ecdysteroids in regulating changes in prothoracic gland cell DNA synthesis during development.…”
Section: Discussionmentioning
confidence: 99%