The 20-hydroxyecdysone-induced cellular arrest in G2 phase is preceded by an inhibition of cyclin expression

Mottier, Violaine; Siaussat, David; Bozzolan, Françoise; Auzoux-Bordenave, Stéphanie; Porcheron, P.; Debernard, Stéphane

doi:10.1016/j.ibmb.2003.09.003

Cited by 24 publications

(33 citation statements)

References 47 publications

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“…In D. melanogaster, pulses of 20E throughout fly development have proved to regulate cell proliferation, differentiation, and programmed cell death in a highly controlled manner. During metamorphosis, for example, ecdysone is a primary regulator of apoptosis in larval tissues such as salivary glands, midgut and neural tissues which are destroyed or remodelled into an "adult" form (Mottier et al, 2004;Tsuzuki et al, 2001). The activation and execution of ecdysis (i.e.…”

Section: Ecdysteroids: a Role As Sex Hormones In Insects?mentioning

confidence: 99%

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Negri¹,

Pellecchia²

2012

Sex Hormones

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Section: Ecdysteroids: a Role As Sex Hormones In Insects?mentioning

confidence: 99%

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Negri¹,

Pellecchia²

2012

Sex Hormones

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“…In arthropods, ecdysteroids can either stimulate cell proliferation or initiate cell differentiation [94][95][96] depending on the level of moulting hormones. This is accompanied by an arrest either at G2 [95,97,98] or at G1/S [99]. Periodic expression of EcR and Usp during the cell cycle and their impact on regulation of cell proliferation was reported recently [100][101][102].…”

Section: Ecdysteroids and Cell Cyclementioning

confidence: 99%

Ecdysteroid hormone action

Spindler

Honl

Tremmel

et al. 2009

Cell. Mol. Life Sci.

103

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Several reviews devoted to various aspects of ecdysone research have been published during the last few years. Therefore, this article concentrates mainly on the considerable progress in ecdysone research observed recently, and will cover the results obtained during the last 2 years. The main emphasis is put on the molecular mode of ecdysteroid receptor-mediated hormone action. Two examples of interaction with other hormonal signalling pathways are described, namely crosstalk with juvenile hormone and insulin. Some selected, recently investigated examples of the multitude of hormonal responses are described. Finally, ecological aspects and some practical applications are discussed.

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“…It was also demonstrated that in B. mori, ecdysteroids inhibit corpus allatum cell DNA synthesis (Gu and Chow, 2003a). Recently Mottier et al (2004) reported that the decrease in cyclin expression is related to 20-hydroxyecdysone-induced inhibition of the IAL-PID2 cell line established from imaginal wing discs of Plodia interpunctella. Further study is needed to clarify the role of ecdysteroids in regulating changes in prothoracic gland cell DNA synthesis during development.…”

Section: Discussionmentioning

confidence: 99%

Temporal changes in DNA synthesis of prothoracic gland cells during larval development and their correlation with ecdysteroidogenic activity in the silkworm, Bombyx mori

Gu¹,

Chow²

2005

J. Exp. Zool.

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DNA synthesis in prothoracic gland cells of the silkworm, Bombyx mori, was studied immunocytochemically after in vivo labeling with 5-bromo-2'-deoxyuridine (BrdU), and its developmental changes during the 3rd, 4th, and last larval instars were examined. During the early stages of both the 3rd and 4th larval instars, a dramatic increase in the number of DNA-synthesizing cells of the prothoracic glands was detected. However, during the latter stages of each instar, the number of DNA-synthesizing cells greatly decreased. The determination of glandular protein content showed that dramatic increases occurred during the latter stages of each larval instar. Comparison of changes in prothoracic gland cell DNA synthesis with ecdysteroidogenic activity showed that the increase in DNA synthesis precedes ecdysteroidogenesis. The cellular mechanism underlying changes in prothoracic gland cell DNA synthesis during the last two larval instars was further analyzed by determining the in vitro DNA synthesis of the glands, their responsiveness to hemolymph growth factors, and changes in the growth-promoting activity of hemolymph during development. It was found that both growth factors and the responsiveness of the prothoracic gland cells to growth factors from hemolymph may play roles in regulating DNA synthesis of gland cells.

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The 20-hydroxyecdysone-induced cellular arrest in G2 phase is preceded by an inhibition of cyclin expression

Cited by 24 publications

References 47 publications

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Ecdysteroid hormone action

Temporal changes in DNA synthesis of prothoracic gland cells during larval development and their correlation with ecdysteroidogenic activity in the silkworm, Bombyx mori

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