The 2,4-D herbicide effects on acetylcholinesterase activity and metabolic parameters of piava freshwater fish (Leporinus obtusidens)

Fonseca, Milene Braga da; Glusczak, Lissandra; Moraes, Bibiana Silveira; Menezes, Charlene; Pretto, Alexandra; Tierno, Miguel Angel; Zanella, Renato; Gonçalves, Fábio Ferreira; Loro, Vânia Lúcia

doi:10.1016/j.ecoenv.2007.08.006

Cited by 88 publications

(38 citation statements)

References 24 publications

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“…In the present study, a significant decrease in body weight gain was monitored in the mice group injected with CMZ alone or CMZ plus vitamin C. Similar responses were observed by Menezes et al (2015) who monitored a reduction in the final weight and specific growth rate of silver catfish exposed to the herbicide 2,4-D dimethylamine salt (DMA) that may be due to CMZ long-term exposure that affects the growth of the exposed animal by altering its metabolism efficacy resulting in the overall increased degeneration of lipids and proteins (Fonseca et al, 2008;Menezes et al, 2015;Dahdouh, Attalah, Djabar, & Kechrid, 2016).…”

Section: Discussionsupporting

confidence: 57%

“…Studies on non-target species showed reduction in final body weight by treatment with herbicide 2,4-D dimethylamine salt (DMA) (Salbego et al, 2010;Menezes et al, 2015) that may be due to changes in their metabolic pathways due to herbicide stress (Fonseca et al, 2008). Decreases in the absolute and relative weights of the spleen and thymus were observed in mice treated with atrazine (Filipov, Pinchuk, Boyd, & Crittenden, 2005;Karrow et al, 2005;Zhang et al, 2011) that may be associated with the inhibition of lymphocyte proliferation and/or the increase of their death (Kamath, Xu, Nagarkatti, & Nagarkatti, 1997;Vandebriel, Spiekstra, Hudspith, Meredith, & Van Loveren, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Immunobiochemical modulations caused by clomazone in Swiss albino mice

Nassef

2017

JoBAZ

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Immunobiochemical modulations caused by clomazone in Swiss albino mice

Nassef

2017

JoBAZ

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“…Induction or inhibition of AChE in fish tissues can influence cholinergic transmission process, thus eliciting undesirable effects [32]. Inhibition of AChE has been reported in fishes exposed to different pesticides [33].…”

Section: Discussionmentioning

confidence: 99%

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

Owolabi

Omotosho

2017

IJT

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“…Detrimental effects of 2,4-D on the AChE activity were reported by Fonseca et al (11), who studied 96 h effects of 1 and 10 mg L -1 2,4-D on Leporinus obtusidens. The AChE activity of muscle tissue was reduced at both concentrations, as was the case at a concentration of 10 mg L -1 for brain tissue.…”

mentioning

confidence: 99%

The sublethal effects of (2,4-Dichlorophenoxy) acetic acid (2,4-D) on narrow-clawed crayfish (Astacus leptodactylus Eschscholtz, 1823)

Benlı

Şahin

Sarıkaya

et al. 2016

Archives of Industrial Hygiene and Toxicology

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2,4-D is a widely used phenoxy herbicide, potentially toxic to humans and biota. The objective of the present study was to reveal short term sublethal effects of 2,4-D on narrow-clawed freshwater crayfish (Astacus leptodactylus Eschscholtz, 1823), based on histology, total haemocyte counts, selected haemolymph parameters, and oxidative stress parameters. In the laboratory conditions crayfish specimens were exposed to 9 mg L -1 of 2,4-D for one week. Experiments were conducted under semi-static conditions in 20 L-capacity aquaria where 10 freshwater crayfish were stocked per aquarium. Exposure (experimental) and control groups were used and the experiments were repeated two times. No mortality and behavioural changes were recorded during the experiments. Total haemocyte counts decreased significantly, while haemolymph glucose levels increased (P<0.05), when compared to the control group. Haemolymph levels of calcium, chloride, sodium, potassium, magnesium, total protein, and lactate did not change. Exposure resulted with increased levels of malondialdehyde (MDA) only in hepatopancreas. However, results of gill FOX assay showed a significant decrease in oxidative stress parameters (P<0.05). MDA levels of gill and abdominal muscle tissues and FOX levels of hepatopancreas and abdominal muscle tissues did not change when compared to the control group. Significant histopathological alterations were observed both in hepatopancreas (multifocal deformations in tubule lumen) and gill tissue (melanisation of gill lamella). Exposure of crayfish even to a sublethal concentration of 2,4-D alters histopathology and lipid peroxidation due to stress. Biomarkers studied here seem to be useful for the assessment of adverse/toxic effects of pesticides on non-target, indicator aquatic organisms.KEY WORDS: haemolymph; herbicide; histology; oxidative stress; toxicity T h e f i r s t s u c c e s s f u l s e l e c t i v e h e r b i c i d e , 2,4-dichlorophenoxy acetic acid (2,4-D), was developed in 1946. It belongs to the phenoxy herbicide family and is still one of the systemic herbicides widely used to control many types of broadleaf weeds (1). It is used to control aquatic vegetation, in pasture and rangeland applications, in cultivated agriculture, forest management, home, and garden. It acts by sustaining high levels of the plant hormone auxin, which results in overstimulation of plant growth and death. In addition to this, it causes changes in the animal nervous system based on receptor interaction/interference of acetylcholine. Furthermore, it inhibits the acetyl cholinesterase (AChE) activity and increases the level of serotonin.Available data on 2,4-D toxicity on aquatic organisms mostly rely on the reports of its acute toxic effects observed in different fish species. Oruc and Uner (4) studied the combined effects of azinphosmethyl and 2,4-D on Oreochromis niloticus to clarify the mode of its action on the cellular defence system. Farah et al. (5) (8); for catfish (Clarias batrachus) by studying micronuclei and erythrocyte alt...

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The 2,4-D herbicide effects on acetylcholinesterase activity and metabolic parameters of piava freshwater fish (Leporinus obtusidens)

Cited by 88 publications

References 24 publications

Immunobiochemical modulations caused by clomazone in Swiss albino mice

Immunobiochemical modulations caused by clomazone in Swiss albino mice

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

The sublethal effects of (2,4-Dichlorophenoxy) acetic acid (2,4-D) on narrow-clawed crayfish (Astacus leptodactylus Eschscholtz, 1823)

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