We study the cosmic X-ray background (CXB) intensity variations on large angular scales using the slew data from the RXTE observatory. We detect intensity variations up to ∼2% on angular scales of 20−40 • . These variations are partly correlated with the local large-scale structure, which allowed us to estimate the emissivity of the local Universe in the energy band 2−10 keV at (8 ± 4) × 10 38 h 75 erg s −1 Mpc −3 . The spectral energy distribution of the large-angular-scale variations is hard and is compatible with that of the CXB, which implies that normal galaxies and clusters of galaxies, whose spectra are typically much softer, do not contribute more than 15% to the total X-ray emissivity of the local Universe. Most of the observed CXB anisotropy (after exclusion of point sources with fluxes > ∼ 10 −11 erg s −1 cm −2 ) can be attributed to low-luminosity AGNs.