“…Finally, a patient with Addison's disease has been studied while maintained on desoxycorticosterone acetate (1.25 mg. intramuscularly at 6 a.m. and 6 p.m.) and cortisone (6.25 mg. orally at 6 a.m. and 6 p.m.) (85). When he remained at bed rest and took identical food and fluid every six hours day and night, the 2The existence of such an adrenocortical rhythm in man is suggested by observations that the renal excretion of 17-ketosteroids (75)(76)(77)(78)(79), neutral reducing lipids (78), and uric acid (8,36,37) is less at night than during the day, as well as by the fact that the numbers of circulating lymphocytes (80) and eosinophils (81)(82)(83) (32). Alterations in the total daily excretion of water and solutes such as urea and phosphate related to increased food intake and protein catabolism during cortisone administration might induce changes in the diurnal excretory pattern.…”