The 17-Ketosteroids: Their Origin, Determination and Significance

Studies in Cushing's Syndrome. Iii. Urinary 17-Ketosteroids in Patients With Bilateral Adrenal Cortical Hyperplasia*

“…(Table III). This observation is in accord with the results of most studies of urinary 17-ketosteroids in Cushing's syndrome (31). It has been found by most investigators that excessive quantities of dehydroisoandrosterone are not present in the urine of patients with adrenal hyperplasia, but that large amounts of this steroid may be present in the urine of patients with adrenal cortical carcinoma (31).…”

The Influence of Cortisone Upon the Diurnal Rhythm of Renal Excretory Function

“…Finally, a patient with Addison's disease has been studied while maintained on desoxycorticosterone acetate (1.25 mg. intramuscularly at 6 a.m. and 6 p.m.) and cortisone (6.25 mg. orally at 6 a.m. and 6 p.m.) (85). When he remained at bed rest and took identical food and fluid every six hours day and night, the 2The existence of such an adrenocortical rhythm in man is suggested by observations that the renal excretion of 17-ketosteroids (75)(76)(77)(78)(79), neutral reducing lipids (78), and uric acid (8,36,37) is less at night than during the day, as well as by the fact that the numbers of circulating lymphocytes (80) and eosinophils (81)(82)(83) (32). Alterations in the total daily excretion of water and solutes such as urea and phosphate related to increased food intake and protein catabolism during cortisone administration might induce changes in the diurnal excretory pattern.…”

The Cause of Hypercalcuria in Sarcoid and Its Treatment With Cortisone and Sodium Phytate 12

“…per day on the largest doses of cortisone. The rise in 17-ketosteroid excretion may represent excretion of cortisone metabolites and improvement in liver function (12). Evidence for the latter was the observed diminution in size of the liver and spleen and the fall in serum alkaline phosphatase to normal values during cortisone administration.…”