The 15th Frank Warren Organic Chemistry Conference

Veale, Clinton G. L.

doi:10.1002/cmdc.201900535

Cited by 4 publications

(4 citation statements)

References 42 publications

(61 reference statements)

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“…These same trends are evident in Africa, where the scope of science falling under the umbrella of chemical biology has expanded from traditional strengths in natural product chemistry, [8,9] organic chemistry, [10,11] and biochemistry, [12] into contemporary programs in enzymology, [13] biocatalysis, [14] bioinorganic chemistry, [15] medicinal chemistry and drug discovery. [16,17] Given the high burden of neglected disease in Africa, [18] the proclivity of chemical biology projects to occur in the multidisciplinary healthcare space [19] make it a particularly important field in Africa.…”

Section: African Research and Visibilitymentioning

confidence: 86%

Section: African Research and Visibilitymentioning

confidence: 90%

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Biological and Medicinal Chemistry in Africa

et al. 2023

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The young, fast‐growing population of Africa means that harnessing the economic benefits of scientific research is critical to sustained and equitable growth in the continent. Moreover, the whole world would benefit from the added intellectual contribution that would come from nurturing African science. The high burden of neglected diseases in Africa makes chemical biology a particularly important field. In this editorial, the reconvergence of science conducted at the interface of chemistry and biology is placed in the context of African participation, its importance to global science and the unique blend of supporting and hindering factors that influence African scientific contributions. The new Biological and Medicinal Chemistry in Africa special collection showcases a broad spectrum of African chemical biology.

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Section: African Research and Visibilitymentioning

confidence: 86%

Section: African Research and Visibilitymentioning

confidence: 90%

Biological and Medicinal Chemistry in Africa

et al. 2023

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“…In the South African context, vast biological diversity and extensive bodies of traditional remedies have meant that both terrestrial and marine natural products have been the dominant force in the search for bioactive chemical compounds, with several notable successes . However, while natural products continue to play a pivotal role in South African drug discovery, modern approaches to medicinal chemistry are making an ever‐increasing footprint in South Africa, particularly within organic chemistry circles; this is possibly best exemplified by the recent success in the discovery of antimalarial MMV390048 . Accordingly, in this review, we discuss some recent highlights in medicinal chemistry research (2016–2020) in which researchers based in South Africa have made a significant contribution through medicinal chemistry methodology.…”

Section: Introductionmentioning

confidence: 99%

Recent Highlights in Anti‐infective Medicinal Chemistry from South Africa

Veale

Müller

2020

ChemMedChem

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Global advancements in biological technologies have vastly increased the variety of and accessibility to bioassay platforms, while simultaneously improving our understanding of druggable chemical space. In the South African context, this has resulted in a rapid expansion in the number of medicinal chemistry programmes currently operating, particularly on university campuses. Furthermore, the modern medicinal chemist has the advantage of being able to incorporate data from numerous related disciplines into the medicinal chemistry process, allowing for informed molecular design to play a far greater role than previously possible. Accordingly, this review focusses on recent highlights in drug-discovery programmes, in which South African medicinal chemistry groups have played a substantive role in the design and optimisation of biologically active compounds which contribute to the search for promising agents for infectious disease.

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“…I would argue that a major reason for the current health of organic chemistry is the strong relationships between its practitioners. Firstly, on a local level, the enthusiastic support of the South African Chemical Institute's (SACI) organic chemistry-focussed, biennial Frank Warren conference 1 is a good indicator of the health of the discipline. This support is also depicted by the more sporadic, but also important, publication of synthetic organic-chemistry-focussed manuscripts in the South African Journal of Chemistry, an open-access journal with a more than a 100 year history.…”

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confidence: 99%

Organic chemistry in South Africa

Otterlo¹

2020

Arkivoc

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It is an absolute honour to be able to preface a special issue on "Organic Chemistry in South Africa" in the 2020 volume of Arkivoc. Many South African organic chemistry practitioners have enthusiastically responded to my invitation to provide manuscripts for this issue, and it is my hope that the papers submitted will reflect the breadth and width of organic chemistry expertise across the country. Reflecting on the "vital signs" of organic chemistry within South Africa, it quickly becomes apparent that there are many complex factors affecting the health of the discipline. I thus decided to undertake my analysis by way of a brief SWOT-type protocol, i.e., strengths, weaknesses, opportunities and threats pertaining to the subject, whilst keeping in mind the potential pitfalls and limitations of this approach. In South Africa, the descriptor "organic chemistry" covers a very broad field, encompassing synthetic methods development to natural product isolation and some arguably more applied fields such as medicinal chemistry, polymer chemistry, catalysis, organometallic and inorganic chemistry (the latter three specifically with respect to ligand design and synthesis). This aspect places the South African organic chemistry community in quite a unique space on the African continent since, apart from a few more northern African countries, the phrase "Organic Chemistry" essentially implies research focussed on natural products chemistry (i.e. isolation and structure elucidation).One of the reasons for the strength of organic chemistry at the geographical tip of Africa is the infrastructure found at many universities there, encompassing equipment and expertise required for organic chemistry to thrive. This includes NMR, mass spectroscopy and X-ray crystallography facilities. It should be noted that these facilities are not equally distributed, with mainly the larger historically-advantaged universities being well equipped. In the last two decades, national equipment programs (through governmental funding agencies) have achieved greater equitability by the creation of regional equipment

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The 15th Frank Warren Organic Chemistry Conference

Cited by 4 publications

References 42 publications

Biological and Medicinal Chemistry in Africa

Biological and Medicinal Chemistry in Africa

Recent Highlights in Anti‐infective Medicinal Chemistry from South Africa

Organic chemistry in South Africa

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