The 15kDa Selenoprotein Expression May Be Regulated Through The AhR Pathway

Galinn, Sarah E.; Rosso, Lauren; Carlson, Bradley A.; Tobe, Ryuta; Naranjo‐Suarez, Salvador; Tsuji, Petra A.

doi:10.1096/fasebj.29.1_supplement.759.9

FASEB j.

2015

DOI: 10.1096/fasebj.29.1_supplement.759.9

|View full text |Cite

The 15kDa Selenoprotein Expression May Be Regulated Through The AhR Pathway

Sarah E. Galinn

Lauren Rosso

Bradley A. Carlson³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing epidemiological and experimental animal data provide substantial support for an abnormal AhR function in tumor cells, implying that AhR may be a novel drug-interfering target. Interestingly, AhR was found to be overexpressed or implicated in key pathological pathways in the two cancer cell lines listed above. , …”

mentioning

confidence: 99%

“…Interestingly, AhR was found to be overexpressed or implicated in key pathological pathways in the two cancer cell lines listed above. 23,24 In addition, 7-isopentenyloxycoumarin was also reported to have neuroprotective effects against N-methyl-D-aspartateinduced cell death in astrocytes and neurons in vitro. 14 It has been shown that AhR is also able to attenuate neuronal excitotoxicity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor

et al. 2017

View full text Add to dashboard Cite

The aryl hydrocarbon receptor (AhR) is a transcription factor activated by a vast array of natural and synthetic ligands. It plays a pivotal role in numerous physiological and pathological responses, such as cell proliferation and differentiation, induction of xenobiotic metabolizing enzymes, response to environmental toxins, and several others. In this study, we investigated the ability of some natural compounds (oxyprenylated ferulic acid and umbelliferone derivatives) and their semisynthetic analogues (e.g., differently substituted 7-alkoxycoumarins) to activate AhR, using a reporter luciferase assay. Among them, we found that 7-isopentenyloxycoumarin was the best AhR activator. Boropinic acid, 7-but-2'-enyloxycoumarin, 7-(2',2'-dimethyl-n-propyloxy)coumarin, 7-benzyloxycoumarin, and 7-(3'-hydroxymethyl-3'-methylallyloxy)coumarin were also active, although to a lesser extent. All the compounds were also analyzed for their ability to inhibit AhR activation, using a reference ligand, 6-formylindolo[3,2-b]carbazole. Data recorded in the present investigation pointed out the importance of a 3,3-dimethylallyloxy side chain attached to the coumarin ring core as a key moiety for AhR activation.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor

et al. 2017

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The 15kDa Selenoprotein Expression May Be Regulated Through The AhR Pathway

Cited by 1 publication

References 0 publications

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor

Contact Info

Product

Resources

About