The −159C/T Polymorphism in the Promoter Region of the CD14 Gene Is Associated With Advanced Liver Disease and Higher Serum Levels of Acute‐Phase Proteins in Heavy Drinkers

Abstract

Our results support the notion that CD14/-159TT homozygous heavy drinkers have higher levels of the LPS-binding acute-phase proteins (LBP and sCD14) than do carriers of the CD14/-159C allele. Also, the CD14/-159TT genotype may be a risk factor for advanced ALD.

Alcoholic Hepatitis: Risk Factors, Pathogenesis, and Approach to Treatment

“…Polymorphisms in the tumor necrosis factor (TNF)-a promoter region are also of potential importance: A meta-analysis of 11 studies found an association between the G238A substitution and AH with odds ratio of 1.47 (Marcos et al, 2009). A single nucleotide polymorphism in the endotoxin binding receptor CD14 may also be associated with increased risk of ALD (Campos et al, 2005).…”

Polymorphisms of the TNF, CD14, and HSPA1B Genes in Patients With Acute Alcohol-Induced Pancreatitis

“…11,12 The C/T polymorphism in location j159 from the transcription initiation site of CD14 gene has been shown to influence the transcription levels. 13 In clinical studies, CD14 j159 C/T polymorphism has been associated with alcoholic liver damage, 14,15 possibly mediated by gut-derived bacterial endotoxins. Endotoxin leakage from the gut has been suggested to be a relevant mechanism in clinical AP.…”

Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?

“…Moreover, the included polymorphisms have been associated with an increased risk of alcoholic liver disease (26,29,30,35), accelerated progression of fibrosis in chronic hepatitis B (36) and endotoxin hyporesponsiveness in humans (21). To include gene variants with the largest possible effect size, we also investigated the wIL1RN*2/*2; IL1B -31Tqx diplotype, because it increases the production of IL-1b more than either of the polymorphisms alone (24,25).…”