The -141C Ins/Del and Taq1A polymorphism in the dopamine D2 receptor gene may confer susceptibility to schizophrenia in Asian populations

Wang, Yurong; Liu, Li; Xin, Lihong; Fan, Dazhi; Ding, Ning; Hu, Yun; Cai, Guoqi; Wang, Li; Xia, Qing; Li, Xiaona; Yang, Xiao; Zou, Yanfeng; Pan, Faming

doi:10.1016/j.jocn.2015.10.052

Cited by 10 publications

(7 citation statements)

References 49 publications

(43 reference statements)

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“…However, the approach is vulnerable to the effect of racial stratification, sample population, and sample content. Sample population issues may also explain the inconsistencies between our results and some meta-analyses conducted in Asia Wang et al, 2016) and even in China (Zhao et al, 2016). China is a vast country with a great geographical distance between north and south.…”

Section: Discussioncontrasting

confidence: 69%

No association between polymorphisms in the promoter region of dopamine receptor D2 gene and schizophrenia in the northern Chinese Han population: A case–control study

et al. 2019

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Background Epidemiological studies found that genetic factors are among the causes of schizophrenia, exclusively the genes involved in the dopamine system. Prior to this, the role of dopamine receptor D2 ( DRD2 ) gene promoter polymorphisms and schizophrenia has been studied extensively, but there are still some uncertainties about these associations. The present study is focusing on the association between the DRD2 gene promoter region polymorphisms and schizophrenia in the northern Chinese Han population. Methods We sequenced 2,111‐bp fragment of DRD2 gene promoter region in 306 schizophrenic patients and 324 healthy controls to find association between DRD2 and schizophrenia. SPSS version 18 0.0 was used to calculate odds ratios (OR), 95% confidence intervals (CIs).The Hardy–Weinberg equilibrium test and the confirmation of haplotypes were calculated using Haploview version 4.1. The association of schizophrenic risk of DRD2 genotypes, alleles, and haplotypes between case and control groups was calculated using the chi‐squared test. PS program was used to calculate the Power analysis. Results The genotype frequencies of rs7116768 ( p = 0.025) and rs1799732 ( p = 0.042) were associated meagerly. After Bonferroni correction, there was no association found between DRD2 gene promoter region with schizophrenia risk in the northern Chinese Han population. Conclusions In this study, we did not find any significant difference between schizophrenia and the polymorphisms of DRD2 gene promoter region. A more forceful conclusion remains to be verified by further confirmatory experiments.

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Section: Discussioncontrasting

confidence: 69%

No association between polymorphisms in the promoter region of dopamine receptor D2 gene and schizophrenia in the northern Chinese Han population: A case–control study

et al. 2019

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“…The DRD2 -141C Ins/Del polymorphism corresponds to a deletion of one cytosine from a run of two cytosines at position -141 of the DRD2 gene ( Arinami et al , 1997 ). This polymorphism has been associated with risk of schizophrenia in different populations ( Arinami et al , 1997 ; Ohara et al , 1998 ; Jonsson et al , 1999a ; Himei et al , 2002 ; Wu et al , 2005 ; Lafuente et al , 2008a , b ; Cordeiro et al , 2009 ; Saiz et al , 2010 ; Xiao et al , 2013 ; Wang et al , 2016 ; Zhao et al , 2016 ), as well as with weight gain ( Lencz et al , 2010 ) and other responses due to schizophrenia drug treatment ( Lencz et al , 2006 ; Zhang et al , 2010 ). Associations have been described with propensity to alcohol dependence in different populations ( Ishiguro et al , 1998 ; Konishi et al , 2004a , b ; Johann et al , 2005 ; Du and Wan, 2009 ; Prasad et al , 2010 ; Lee et al , 2013 ), suicide attempts ( Suda et al , 2009 ), psychiatric disorders ( Kishida et al , 2004 ; Ujike et al , 2009 ; Lencer et al , 2014 ), different responses to medication and higher quit rates in smokers ( Lerman et al , 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

et al. 2018

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The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of TaqIA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food intake and adiposity parameters in a cohort of children. The sample consisted of 270 children followed until 7 to 8 years old. DNA was extracted from blood and polymorphisms were detected by PCR-RFLP analysis. Food intake and nutritional status were compared among individuals with different SNP genotypes. Children carrying the A1 allele (TaqIA) had higher energy of lipid dense foods (LDF) when compared with A2/A2 homozygous children at 7 to 8 years old (GLM p=0.004; Mann Whitney p=0.005). No association was detected with -141C Ins/Del polymorphism. To our knowledge, this is the first association study of the DRD2 TaqIA and -141C Ins/Del polymorphism with food intake and anthropometric parameters in children. DRD2 TaqIA polymorphism has been associated with a reduction in D2 dopamine receptor availability. Therefore, the differences observed in LDF intake in our sample may occur as an effort to compensate the hypodopaminergic functioning.

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“…Third, this study only studies the association between 5‐HT 3A receptor gene expression and risperidone effect. Many other molecules besides 5‐HT3A can affect a patient's responsiveness to antipsychotics such as DRD2 (‐141C Ins/Del) and its neighboring ANKK1 (Taq1A), plus metabolic enzymes such as CYP2D6 (Almoguera et al., 2013; Miura et al., 2016; Wang et al., 2016). Further study should be performed to examine the effects of interaction of these genes on 5‐HT 3A receptor gene expression and risperidone effect.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

et al. 2017

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IntroductionThe relationship between peripheral 5‐HT3A receptor mRNA level and risperidone efficiency in paranoid schizophrenia patients is still unknown.MethodsA total 52 first‐episode and drug‐naive paranoid schizophrenia patients who were treated with risperidone and 53 matched healthy controls were enrolled. Patients were naturalistically followed up for 8 weeks. Positive and Negative Syndrome Scale (PANSS) was applied to assess symptom severity of the patients at baseline and at the end of 8th week.ResultsThere was no difference in 5‐HT3A receptor mRNA level between paranoid schizophrenia patients and healthy controls at baseline (p = .24). Among 47 patients who completed 8‐week naturalistic follow‐up, 37 were responders to risperidone treatment. 5‐HT3A receptor mRNA level of paranoid schizophrenia patients did not change in overall patients after 8‐week treatment with risperidone (p = .29). However, 5‐HT3A receptor mRNA level in responders increased significantly (p = .04), but not in nonresponders (p = .81).ConclusionsSuccessful treatment with risperidone increases 5‐HT3A receptor gene expression in patients with paranoid schizophrenia, indicating that 5‐HT3A receptor may be involved in the mechanism of risperidone effect.

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The -141C Ins/Del and Taq1A polymorphism in the dopamine D2 receptor gene may confer susceptibility to schizophrenia in Asian populations

Cited by 10 publications

References 49 publications

No association between polymorphisms in the promoter region of dopamine receptor D2 gene and schizophrenia in the northern Chinese Han population: A case–control study

No association between polymorphisms in the promoter region of dopamine receptor D2 gene and schizophrenia in the northern Chinese Han population: A case–control study

Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development

Successful treatment with risperidone increases 5‐HT 3A receptor gene expression in patients with paranoid schizophrenia – data from a prospective study

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