The 13C-urea breath test for early assessment of Helicobacter pylori eradication

Bazzoli, Franco; Zagari, R.M.; Fossi, S.; Pozzato, P.; Simoni, Patrizia; Roda, Ângela; Roda, Enrico

doi:10.1016/0016-5085(95)22891-8

Cited by 4 publications

(3 citation statements)

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“…For individual diagnostic use, the correlation between bacterial density and urease activity has already been evaluated in adults [11,12], and some authors suggested the introduction of a gray zone to increase the reliability of the test [2]. In children, such a quantitative relation remains to be evaluated.…”

mentioning

confidence: 99%

¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

Vincent¹,

Michaud

Lasalle

et al. 1999

Helicobacter

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mentioning

confidence: 99%

¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

Vincent¹,

Michaud

Lasalle

et al. 1999

Helicobacter

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“…Although current guidelines state that UBTs be delayed until at least 4±6 weeks after the end of eradication treatment has ®nished, two independent studies have shown that over 85% of 13 C-UBTs are positive only 2 weeks after failed eradication treatment. 44,45 A recent, albeit extremely limited, study has suggested that H 2 -antagonists may also produce false negative UBT results if taken in high doses. 46 This may be an important observation if correct, as patients are often treated with H 2 -antagonists whilst awaiting breath testing.…”

Section: Concomitant Medicationmentioning

confidence: 99%

urea breath tests for detecting Helicobacter pylori

Goddard¹,

Logan²

1997

Aliment Pharmacol Ther

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The urea breath test (UBT) is the most sensitive and specific non‐invasive test for the detection of Helicobacter pylori infection both before and after treatment. Labelling of the urea with either 13C or 14C has relative advantages and disadvantages. 13C‐UBTs are both safe and well‐validated, and have the additional advantage that they can be used in children. However, the initial capital costs of 13CO2 analysis are large compared to those for 14CO2. The protocol details for use of the 13C‐UBT are variable: a test meal is important if urea solution is to be used and a single sample time point at 30 min is adequate. The recent development of novel formulations of 13C urea and new analytical techniques for the measurement of 13CO2 should allow reduction in the length of the test and its cost; they may herald a more widespread clinical application of this useful test.

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“…The magnitude of the UBT or H pylori immunoglobulin G serology cannot be used to predict the presence or absence of gastroduodenal ulcers (37). The UBT is usually repeated one month after eradication therapy, but may show successful eradication earlier (38).…”

Section: Diagnosis Of Human Infectionmentioning

confidence: 99%

Helicobacter pylori: From Infection to Cure

Thomson

1996

Canadian Journal of Gastroenterology

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Over 380 abstracts, presentations and posters of recent advances were highlighted at the European and InternationalHelicobacter pylorimeeting held July 7 to 9, 1995 in Edinburgh, Scotland. New advances abound, with major interest focusing on the simple, safe, inexpensive new `gold standard’ forH pylorieradication therapy: a single week of tid omeprazole 20 mg, metronidazole 400 mg and clarithromycin 250 mg, or omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg. To avoid false negative results, two biopsies must be taken from the antrum and two from the gastric body at least four weeks after completion of eradication therapy, and ideally should be supplemented with at least one furtherH pyloritest such as a biopsy for urease activity or culture, or a urea breath test. While most patients with a gastric or duodenal ulcer (DU) who do not consume nonsteroidal anti-inflammatory drugs are infected withH pylori, the association is much less apparent in those with a DU who present with an upper gastrointestinal hemorrhage.H pylorieradication for nonulcer dyspepsia is not widely recommended, and the patient with a DU given effectiveH pylorieradication who presents with dyspepsia likely has erosive esophagitis rather than recurrent DU orH pylori. Gastroenterologists are at increased risk ofH pyloriinfection, particularly older gastroenterologists who are very busy endoscopists.

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The 13C-urea breath test for early assessment of Helicobacter pylori eradication

Cited by 4 publications

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¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

urea breath tests for detecting Helicobacter pylori

Helicobacter pylori: From Infection to Cure

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The 13C-urea breath test for early assessment of Helicobacter pylori eradication

Cited by 4 publications

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13C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

13C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

urea breath tests for detecting Helicobacter pylori

Helicobacter pylori: From Infection to Cure

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Product

Resources

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¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection

¹³C‐Urea Breath Test and Gastric Mucosal Colonization by Helicobacter pylori in Children: Quantitative Relation and Usefulness for Diagnosis of Infection