The 13C-octanoic acid breath test for gastric emptying in health volunteers: Clinical and analytical reproducibility

Bureš, Jan; Kopáčová, Marcela; Voříšek, Viktor; Bukač, Josef; Douda, Tomáš; Rejchrt, Stanislav; Široký, Milan; Živný, Pavel; Palička, Vladimír

doi:10.1016/s0016-5085(08)82312-8

Cited by 2 publications

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“…confirmed in the previous study [22]. In children with chronic intestinal pseudo-obstruction, the increased amplitude of the gastric electrical activity recorded by the EGG after a meal and erythromycin administration seemed to be only partly due to the increase in antral motor activity.…”

Section: Plos Onesupporting

confidence: 84%

“…These findings provide a possible explanation of rivastigmine-associated dyspepsia in the clinical setting. In humans, there is a correlation of EGG and gastric emptying rate estimated by 13 C-octanoic acid breath test in healthy volunteers [ 21 ]. In patients with Roux-en-Y reconstruction after previous Billroth gastrectomy, an inverse trend between severity of dyspepsia and normal slow-wave rhythm percent activity in EGG was confirmed in the previous study [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…In humans, there is a correlation of EGG and gastric emptying rate estimated by 13 C-octanoic acid breath test in healthy volunteers [ 21 ]. In patients with Roux-en-Y reconstruction after previous Billroth gastrectomy, an inverse trend between severity of dyspepsia and normal slow-wave rhythm percent activity in EGG was confirmed in the previous study [ 22 ]. In children with chronic intestinal pseudo-obstruction, the increased amplitude of the gastric electrical activity recorded by the EGG after a meal and erythromycin administration seemed to be only partly due to the increase in antral motor activity.…”

Section: Discussionmentioning

confidence: 99%

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The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

Tsianou,

Kvetina,

Radochova

et al. 2023

PLoS ONE

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Background Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer’s disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs. Methods Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes). Results In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5–2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577–1375; p = 0.001) and T10 (992.5; 385–2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549–5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434–1476; p = 0.002) and T8 (799; 435–1463 μV2; p = 0.004). Conclusions Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.

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Section: Plos Onesupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

Tsianou,

Kvetina,

Radochova

et al. 2023

PLoS ONE

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“…Examination of the gastric motility function uses gastric emptying scintigraphy, 13 C-acetate or 13 C-octanoic acid breath tests, electrogastrography, magnetic resonance imaging, antroduodenal manometry, ancillary testing (including barostat and satiety testing) or EndoFLIP (Endoscopic Functional Lumen Imaging Probe: high-resolution impedance planimetry system). EndoFLIP may be also used for the assessment of oesophageal motility function, in fact, it can replace oesophageal manometry in some patients (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Investigation of the intestinal motor function is the most demanding and the least accurate.…”

Section: Introductionmentioning

confidence: 99%

Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study

Bureš

Radochová

Kvĕtina

et al. 2023

Acta Med. (Hradec Kralove, Czech Repub.)

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Background: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal transit time, intra-luminal pH, pressure and temperature). Gastrointestinal motility functions of experimental pigs are very similar to those of humans. That is why porcine studies have already provided suitable experimental models for several preclinical projects. Aims: The aim of our study was to adopt methods of non-invasive wireless monitoring of gastrointestinal functions in experimental pigs. Methods: Five experimental adult female pigs were enrolled into the study. Wireless motility capsules were delivered into the porcine stomach endoscopically. Gastrointestinal transit and intra-luminal conditions were recorded for five days. Results: Records of animals provided good (3 pigs) or very good quality files (2 pigs). 31150 variables were evaluated. Mean time of the presence of capsules in the stomach was 926 ± 295 min, transfer of a capsule from the stomach into the duodenum lasted 5–34 min. Mean small intestinal transit time was 251 ± 43 min. Food intake was associated with an increase of gastric luminal temperature and a decrease of intra-gastric pressure. The highest intra-luminal pH was present in the ileum. The highest temperature and the lowest intra-luminal pressure were found in the colon. All data displayed a substantial inter-individual variability. Conclusions: This pilot study has proven that a long-term function monitoring of the gastrointestinal tract by means of wireless motility capsules in experimental pigs is feasible. However, both ketamine-based induction of general anaesthesia as well as long-lasting general anaesthesia (> 6 hours) should be avoided to prevent retention of a capsule in the porcine stomach.

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The 13C-octanoic acid breath test for gastric emptying in health volunteers: Clinical and analytical reproducibility

Cited by 2 publications

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The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study

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