The 12 Years Preceding Mild Cognitive Impairment Due to Alzheimer’s Disease: The Temporal Emergence of Cognitive Decline

Mistridis, Panagiota; Krumm, Sabine; Monsch, Andreas U.; Berres, Manfred; Taylor, Kirsten I.

doi:10.3233/jad-150137

Cited by 88 publications

(74 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The RAVLT measures learning over trials as well as immediate and delayed recall. Whereas changes in both learning and immediate/delayed recall have been associated with healthy aging (Balthazar, Yasuda, Cendes, & Damasceno, 2010; Vyhnalek et al, 2014), we hypothesized that WM abnormalities would be more sensitive in predicting changes in delayed recall performance, which has been shown to be a strong predictor of conversion from healthy aging to MCI or AD (Albert et al, 2001; Hamel et al, 2015; Mistridis, Krumm, Monsch, Berres, & Taylor, 2015; Papp et al, 2015). …”

mentioning

confidence: 99%

Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer’s Disease

Lancaster

Seidenberg

Smith

et al. 2016

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Objective White matter (WM) integrity within the mesial temporal lobe (MTL) is important for episodic memory (EM) functioning. The current study investigated the ability of diffusion tensor imaging (DTI) in MTL WM tracts to predict 3-year changes in EM performance in healthy elders at disproportionately higher genetic risk for Alzheimer’s disease (AD). Method Fifty-one cognitively intact elders (52% with family history of dementia and 33% possessing an Apolipoprotein E ε4 allelle) were administered the Rey Auditory Verbal Learning Test (RAVLT) at study entry and at 3-year follow-up. DTI scanning, conducted at study entry, examined fractional anisotropy and mean, radial and axial diffusion within three MTL WM tracts: uncinate fasciculus (UNC), cingulate-hippocampal (CHG), and fornix-stria terminalis (FxS). Correlations were performed between residualized change scores computed from RAVLT trials 1–5, immediate recall, and delayed recall scores and baseline DTI measures, MTL gray matter (GM) and WM volumes, demographics, and AD genetic and metabolic risk factors. Results Higher MTL mean and axial diffusivity at baseline significantly predicted 3-year changes in EM, whereas baseline MTL GM and WM volumes, family history, and metabolic risk factors did not. Both ε4 status and DTI correlated with change in immediate recall. Conclusions Longitudinal EM changes in cognitively intact, healthy elders can be predicted by disruption of the MTL WM microstructure. These results are derived from a sample with a disproportionately higher genetic risk for AD, suggesting that the observed WM disruption in MTL pathways may be related to early neuropathological changes associated with the preclinical stage of AD.

show abstract

mentioning

confidence: 99%

Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer’s Disease

Lancaster

Seidenberg

Smith

et al. 2016

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

“…Deficits on neuropsychological test outcomes have been demonstrated 2-8 years prior to a clinical mild CI diagnosis [8] and up to 18 years prior to dementia onset [9]. Such subtle cognitive changes may go undetected and are unlikely to incur the care costs associated with the more advanced stages of cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

The Economics of Cognitive Impairment: Volunteering and Cognitive Function in the HILDA Survey

Hosking

Anstey²

2016

Gerontology

View full text Add to dashboard Cite

Background: The economic impact of older-age cognitive impairment has been estimated primarily by the direct and indirect costs associated with dementia care. Other potential costs associated with milder cognitive impairment in the community have received little attention. Objective: To quantify the cost of nonclinical cognitive impairment in a large population-based sample in order to more fully inform cost-effectiveness evaluations of interventions to maintain cognitive health. Methods: Volunteering by seniors has economic value but those with lower cognitive function may contribute fewer hours. Relations between hours volunteering and cognitive impairment were assessed using the Household, Income and Labour Dynamics in Australia (HILDA) survey data. These findings were extrapolated to the Australian population to estimate one potential cost attributable to nonclinical cognitive impairment. Results: In those aged ≥60 years in HILDA (n = 3,127), conservatively defined cognitive impairment was present in 3.8% of the sample. Impairment was defined by performance ≥1 standard deviation below the age- and education-adjusted mean on both the Symbol Digit Modalities Test and Backwards Digit Span test. In fully adjusted binomial regression models, impairment was associated with the probability of undertaking 1 h 9 min less volunteering a week compared to being nonimpaired (β = -1.15, 95% confidence interval -1.82 to -0.47, p = 0.001). In the population, 3.8% impairment equated to probable loss of AUD 302,307,969 per annum estimated by hours of volunteering valued by replacement cost. Conclusion: Nonclinical cognitive impairment in older age impacts upon on the nonmonetary economy via probable loss of volunteering contribution. Valuing loss of contribution provides additional information for cost-effectiveness evaluations of research and action directed toward maintaining older-age cognitive functioning.

show abstract

“…A correction for short-term practice effects will be carried out based on previous work [19]. Table 3 shows the neuropsychological subtests used in this study [20]. The 15 variables resulting from neuropsychological assessment are converted into standard scores (z-scores) based on a normative sample [21], and the z-score changes from baseline are calculated.…”

Section: Methodsmentioning

confidence: 99%

Association between changes in cerebral grey matter volume and postoperative cognitive dysfunction in elderly patients: study protocol for a prospective observational cohort study

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundCognitive decline is frequently observed in elderly patients after major surgery. The pathophysiology of postoperative cognitive dysfunction (POCD) remains unclear. The aim of our investigation is to identify potential associations between brain volume change and POCD in elderly patients undergoing major surgery.MethodsThis is a prospective observational cohort study approved by the regional ethics board. We intend to compare specific brain volumes (hippocampus, lateral ventricle, total grey matter volume, regional cortical thickness) on magnetic resonance imaging and cognitive functions determined by a neuropsychological assessment battery in 70 study participants aged ≥65 years before and 3 and 12 months after major noncardiac surgery. Thirty volunteers will be included as matched nonsurgical controls. The primary endpoint of the study is the change in hippocampal volume over time in patients with and without POCD. The secondary endpoint is the correlation between the change in cerebral volume and cognitive function. We will follow the STROBE guidelines for reporting the results of observational studies.DiscussionWe hypothesize that surgery under general anesthesia is associated with a loss of cerebral grey matter, and that the degree of postoperative cognitive dysfunction correlates with the extent of atrophy in areas of the brain that are relevant for cognitive functions. The validation of reproducible anatomical biomarkers, such as the specific brain volumes examined in our cohort, may serve to evaluate the effect of preventive strategies and treatment interventions for POCD in follow-up studies.Trial registrationClinicaltrials.gov NCT02045004. Registered 22 January 2014. Kofam.ch SNCTP000001751. Registered 21 April 2016 (retrospectively registered).

show abstract

The 12 Years Preceding Mild Cognitive Impairment Due to Alzheimer’s Disease: The Temporal Emergence of Cognitive Decline

Cited by 88 publications

References 56 publications

Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer’s Disease

Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer’s Disease

The Economics of Cognitive Impairment: Volunteering and Cognitive Function in the HILDA Survey

Association between changes in cerebral grey matter volume and postoperative cognitive dysfunction in elderly patients: study protocol for a prospective observational cohort study

Contact Info

Product

Resources

About