The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991–1992 and 2001–2002

Grant, Bridget F.; Dawson, Deborah A.; Stinson, Frederick S.; Chou, S. Patricia; Dufour, Mary C.; Pickering, Roger P.

doi:10.1016/j.drugalcdep.2004.02.004

Cited by 1,381 publications

(1,186 citation statements)

References 46 publications

(45 reference statements)

Supporting

Mentioning

1,097

Contrasting

Unclassified

Order By: Relevance

“…In the U.S., 7% of the adult population meet the definition for alcohol misuse or dependence, thereby exceeding the prevalence of hepatitis C by five-fold (Grant et al, 1994). Similar data exist for some countries in Europe, including Germany, where 1.5 million individuals are alcohol-dependent and approximately 3 million people have alcohol-associated organ damage (Deutsche Hauptstelle fü r Suchtfragen, 2003).…”

Section: Epidemiology Of Alcohol and Hepatocellular Cancermentioning

confidence: 58%

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Seitz

Stickel

2006

Biological Chemistry

276

178

View full text Add to dashboard Cite

Hepatocellular cancer is the fifth most frequent cancer in men and the eighth in women worldwide. Established risk factors are chronic hepatitis B and C infection, chronic heavy alcohol consumption, obesity and type 2 diabetes, tobacco use, use of oral contraceptives, and aflatoxin-contaminated food. Almost 90% of all hepatocellular carcinomas develop in cirrhotic livers. In Western countries, attributable risks are highest for cirrhosis due to chronic alcohol abuse and viral hepatitis B and C infection. Among those with alcoholic cirrhosis, the annual incidence of hepatocellular cancer is 1-2%. An important mechanism implicated in alcohol-related hepatocarcinogenesis is oxidative stress from alcohol metabolism, inflammation, and increased iron storage. Ethanolinduced cytochrome P-450 2E1 produces various reactive oxygen species, leading to the formation of lipid peroxides such as 4-hydroxy-nonenal. Furthermore, alcohol impairs the antioxidant defense system, resulting in mitochondrial damage and apoptosis. Chronic alcohol exposure elicits hepatocyte hyperregeneration due to the activation of survival factors and interference with retinoid metabolism. Direct DNA damage results from acetaldehyde, which can bind to DNA, inhibit DNA repair systems, and lead to the formation of carcinogenic exocyclic DNA etheno adducts. Finally, chronic alcohol abuse interferes with methyl group transfer and may thereby alter gene expression.

show abstract

Section: Epidemiology Of Alcohol and Hepatocellular Cancermentioning

confidence: 58%

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Seitz

Stickel

2006

Biological Chemistry

276

178

View full text Add to dashboard Cite

show abstract

“…Among the most concerning comorbidities in juvenile onset BPD is the link with cigarette smoking and substance use disorders (SUD; including drug or alcohol abuse or dependence). Recent epidemiological data suggests that SUD occurs in up to 15% of the adult population (Kessler, et al, 2005) with a one year prevalence of 1.4% and 0.6% for drug abuse and dependence (Compton, et al, 2007); and 4.7% and 3.8% for alcohol abuse and dependence (Grant, et al, 2004). These data also show the frequent onset of both alcohol and drug use disorders during adolescence (Compton, et al, 2007, Grant, et al, 2004, Kessler, et al, 2005.…”

Section: Introductionmentioning

confidence: 91%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…For example, in 1991 the ratio of men to women was 3.3:1 in alcohol treatment facilities (Dawson 1996), while the male to female ratio of alcohol use disorders in the population for that time period was estimated to be 2.7:1 (Grant et al, 1994). Brady and Ashley (2005) concluded that the gender ratio of 2.3:1 in U.S. substance abuse treatment facilities in 2002 was lower than would be expected by the gender ratio of prevalence of alcohol and drug use disorders in the population.…”

Section: Gender Disparities Among Participants In Substance Abuse Trementioning

confidence: 99%

Substance abuse treatment entry, retention, and outcome in women: A review of the literature

Greenfield

Brooks

Gordon

et al. 2007

Drug and Alcohol Dependence

881

782

View full text Add to dashboard Cite

This paper reviews the literature examining characteristics associated with treatment outcome in women with substance use disorders. A search of the English language literature from 1975 to 2005 using Medline and PsycInfo databases found 280 relevant articles. Ninety percent of the studies investigating gender differences in substance abuse treatment outcomes were published since 1990, and of those, over 40% were published since the year 2000. Only 11.8% of these studies were randomized clinical trials. A convergence of evidence suggests that women with substance use disorders are less likely, over the lifetime, to enter treatment compared to their male counterparts. Once in treatment, however, gender is not a significant predictor of treatment retention, completion, or outcome. Gender-specific predictors of outcome do exist, however, and individual characteristics and treatment approaches can differentially affect outcomes by gender. While women-only treatment is not necessarily more effective than mixed-gender treatment, some greater effectiveness has been demonstrated by treatments that address problems more common to substance-abusing women or that are designed for specific subgroups of this population. There is a need to develop and test effective treatments for specific subgroups such as older women with substance use disorders, as well as those with co-occurring substance use and psychiatric disorders such as eating disorders. Future research on effectiveness and cost-effectiveness of gender-specific versus standard treatments, as well as identification of the characteristics of women and men who can benefit from mixed-gender versus single-gender treatments, would advance the field.

show abstract

The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991–1992 and 2001–2002

Cited by 1,381 publications

References 46 publications

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Substance abuse treatment entry, retention, and outcome in women: A review of the literature

Contact Info

Product

Resources

About