2006
DOI: 10.1210/jc.2005-0919
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The 103I Variant of the Melanocortin 4 Receptor Is Associated with Low Serum Triglyceride Levels

Abstract: Our study suggests an influence of MC4R activity on triglyceride levels in cardiovascular patients.

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Cited by 24 publications
(23 citation statements)
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References 28 publications
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“…Therefore, we hypothesised that a more active form of the MC4R linked with the minor A-allele entails a reduced SCD 1 activity, resulting in reduced TG synthesis and a more efficient postprandial response. Previous studies have also reported the relationship between TG plasma levels and MC4R variations [79]. These results suggest that the rs12970134 polymorphism near the MC4R gene may partly explain the inter-individual differences in postprandial lipoprotein response in healthy subjects.…”
Section: Evidence From the Postprandial Statesupporting
confidence: 58%
See 1 more Smart Citation
“…Therefore, we hypothesised that a more active form of the MC4R linked with the minor A-allele entails a reduced SCD 1 activity, resulting in reduced TG synthesis and a more efficient postprandial response. Previous studies have also reported the relationship between TG plasma levels and MC4R variations [79]. These results suggest that the rs12970134 polymorphism near the MC4R gene may partly explain the inter-individual differences in postprandial lipoprotein response in healthy subjects.…”
Section: Evidence From the Postprandial Statesupporting
confidence: 58%
“…Previously, an independent genome-wide association study identified four variants (rs12970134, rs477181, rs502933, and rs4450508) in high linkage disequilibrium downstream of MC4R associated with obesity-related quantitative traits, of which the most strongly associated variant was rs12970134 SNP [78]. In addition, previous data from Bronner et al suggest an influence of MC4R activity on triglyceride levels in cardiovascular patients [79]. Looking for additional physiological pathways underlying MC4R effects on lipoprotein metabolism, we explored whether the presence of the rs12970134 polymorphism near the MC4R gene could modulate postprandial lipid metabolism in a healthy population.…”
Section: Evidence From the Postprandial Statementioning
confidence: 99%
“…Previous research reported that MC4R gene was associated with obesity in human, serum triglyceride and energy expenditure (Dempfle et al, 2004;Bronner et al, 2006;Zobel et al, 2009). Many studies have been reported that MC4R also associated with economic traits in some animals.…”
Section: Introductionmentioning
confidence: 99%
“…Alternatively, SNPs may also have a beneficial role by offering a degree of protection against obesity. Recent evidence has demonstrated that the infrequent V103I polymorphism in MC4R is negatively associated with serum triglyceride levels, body mass index, and obesity [71,72]. As such, genetic variations in MC4R can lead to both loss and gain of function [73].…”
Section: Future Challengesmentioning
confidence: 99%