The 10-Year Prognosis and Prevalence of Brugada-Type Electrocardiograms in Elderly Women

Yeh, Sherri Shih-Fan; Chen, Yi Jen; Wu, I-Chien; Hsu, Chih‐Cheng; Chen, Tzu‐Yu; Tseng, Wei‐Ting; Tang, Feng-Cheng; Wang, Chi-Chung; Juan, Chung-Chou; Chiu, Hou‐Chang; Lo, Huey‐Ming; Yang, Dun-Hui; Juang, Jyh‐Ming Jimmy; Hsiung, Chao A.

doi:10.1097/jcn.0000000000000722

Cited by 1 publication

(2 citation statements)

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“…Furthermore, women diagnosed with BrS are less likely to experience arrhythmic events (syncope, aborted cardiac arrest, and documented ventricular fibrillation) ( 18 , 19 ). Following similar data, BrS ECG patterns are not uncommon in elderly women, but are not associated with an increased risk of mortality ( 21 , 22 ). Recently, a new study demonstrated that women with BrS less frequently presented with a type 1 ECG pattern, had a higher rate of family history of SCD, and had less sustained ventricular arrhythmias on electrophysiological study, despite not constituting a risk-free group.…”

Section: Clinical Findingsmentioning

confidence: 52%

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Brugada Syndrome in Women: What Do We Know After 30 Years?

Martínez-Barrios

Arbelo

César

et al. 2022

Front. Cardiovasc. Med.

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Brugada syndrome (BrS) was initially described in 1992 by Josep and Pedro Brugada as an arrhythmogenic disease characterized by ST segment elevation in the right precordial leads and increased risk of sudden cardiac death (SCD). Alterations in the SCN5A gene are responsible for approximately 30% of cases of BrS, following an autosomal dominant pattern of inheritance. However, despite its autosomal transmission, sex-related differences are widely accepted. BrS is more prevalent in males than in females (8–10 times), with males having a 5.5-fold higher risk of SCD. There are also differences in clinical presentation, with females being more frequently asymptomatic and older than males at the time of diagnosis. Some factors have been identified that could explain these differences, among which testosterone seems to play an important role. However, only 30% of the available publications on the syndrome include sex-related information. Therefore, current findings on BrS are based on studies conducted mainly in male population, despite the wide acceptance of gender differences. The inclusion of complete clinical and demographic information in future publications would allow a better understanding of the phenotypic variability of BrS in different age and sex groups helping to improve the diagnosis, management and risk management of SCD.

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Section: Clinical Findingsmentioning

confidence: 52%

“…A personalized approach should be done before ICD implantation. At our acknowledgement, the first and only study focused on elderly BrS women was published in 2020, showing a not infrequent BrS pattern in the ECG but associated with a lower risk of malignant arrhythmias and SCD ( 21 ).…”

Section: Age Differences In Womenmentioning

confidence: 99%