The 1,2,4‐Triazines

Erickson, John

doi:10.1002/9780470186589.ch2

Cited by 11 publications

(1 citation statement)

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“…Compounds containing the 1,2,4-triazine moiety are found in natural materials and some of them show biological activity. Several reviews dealing with 1,2,4-triazines have appeared, particularly on account of their biochemical properties [16,18,24,26,[28][29][30][31][32]. The parent compound 2 was prepared for the first time by Paulder and Barton in 1966 [33].…”

Section: Introductionmentioning

confidence: 99%

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Oliva¹,

Laza²,

Ocáriz³

2011

Modern Heterocyclic Chemistry

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Section: Introductionmentioning

confidence: 99%

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Oliva¹,

Laza²,

Ocáriz³

2011

Modern Heterocyclic Chemistry

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Synthesis and Antitumor Activity of New Substituted Mercapto‐1,2,4‐Triazine Derivatives, Their Thioglycosides, and Acyclic Thioglycoside Analogs

Nassar

2013

Journal of Heterocyclic Chem

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View this article online at wileyonlinelibrary.com. New 1,2,4-triazine and their derived thioglycoside derivatives were synthesized from 5,6-diphenyl-1,2,4triazine-3-thiol. Furthermore, the corresponding acyclic thioglycoside analogs were synthesized from the corresponding mercapto derivatives and acyclic oxygenated alkyl halides. The newly synthesized compounds were evaluated for their antitumor activity and some of them showed high inhibition activities.

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A general synthesis of as‐triazines and bis‐as‐triazines

Culbertson

Parr

1967

Journal of Heterocyclic Chem

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The most important syntheses of as-triazines have received some amount of systematic study; these include semicarbazide, thiosemicarbazide or aminoguanidine reactions with 1,2-dicarbonyl compounds or their monoximes, with a-keto acids or their esters or amides, or with a-hydroxy ketones (1). The parent compound, 1,2,4-triazine, has only recently been prepared for the first time (2).Recent publications by Case (3,4) report amidrazones (hydrazidines) of the formula RC-(=NH) NHNH2 undergo cyclocondensation readily with diketones such as benzil and pyridil to form 3,5,6-trisubstituted 1,2,4-triazines (astriazines) of formula I.We have recently been concerned with t h e study of various heteroaromatic systems, and now wish to report that amidrazones of the aforesaid formula and bis-amidrazonesof the formula R'[C-(=NH)NHNH2 l2 will also undergo cyclocondensation readily with glyoxal (Ar-COCHO) and bis-glyoxalyl [Ar'(COCH0)2 J compounds t o form I II 111 I V COCHO 8 -2H20 COCHO Vlll V, X -H VI. X . NOp VI1.X O H I X . X = H X . X -NO2

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The 1,2,4‐Triazines

Cited by 11 publications

References 70 publications

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Synthesis and Antitumor Activity of New Substituted Mercapto‐1,2,4‐Triazine Derivatives, Their Thioglycosides, and Acyclic Thioglycoside Analogs

A general synthesis of as‐triazines and bis‐as‐triazines

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