Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1

Jiang, Xia; Li, Dongyun; Wang, Guiqi; Liu, Jue; Su, Xingkai; Yu, Weifang; Wang, Yuanyuan; Zhai, Congjie; Liu, Yuegeng; Zhao, Zhenze

doi:10.3892/or.2020.7502

Cited by 12 publications

(10 citation statements)

References 38 publications

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“…Further studies have shown that activated IRE1 and PERK signaling pathways increase the expression of MALAT1, which promote colorectal cancer (CRC) cell migration. Bioinformatic analysis has indicated XBP1 and ATF4 binding sites within the MALAT1 gene promoter region [ 87 ]. It has been believed that ER stress-regulated lncRNAs play critical roles in tumor progression.…”

Section: Er Stress Regulates Ncrnas Expressionmentioning

confidence: 99%

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

Zhao

Zeng

2020

J Hematol Oncol

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To survive, cancer cells are subjected to various internal and external adverse factors, including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these factors result in the accumulation of unfolded proteins in the endoplasmic reticulum, which leads to a condition termed endoplasmic reticulum stress (ER stress) and triggers the unfolded protein response (UPR). UPR downstream components strictly control transcription and translation reprogramming to ensure selective gene expression, including that of non-coding RNA (ncRNAs), to adapt to adverse environments. NcRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play important roles in regulating target gene expression and protein translation, and their aberrant expression is related to tumor development. Dysregulation of ncRNAs is involved in the regulation of various cellular characteristics of cancer cells, including growth, apoptosis, metastasis, angiogenesis, drug sensitivity, and tumor stem cell properties. Notably, ncRNAs and ER stress can regulate each other and collaborate to determine the fate of tumor cells. Therefore, investigating the interaction between ER stress and ncRNAs is crucial for developing effective cancer treatment and prevention strategies. In this review, we summarize the ER stress-triggered UPR signaling pathways involved in carcinogenesis followed by the mutual regulation of ER stress and ncRNAs in cancer, which provide further insights into the understanding of tumorigenesis and therapeutic strategies.

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Section: Er Stress Regulates Ncrnas Expressionmentioning

confidence: 99%

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

Zhao

Zeng

2020

J Hematol Oncol

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“…Moreover, in CRC tissue samples, MALAT1 is positively regulated with the X‑box‑binding protein 1 (XBP1) and ATF4 binding sites. Therefore, the IRE1/XBP1 and PERK/ATF4 signaling pathways are involved in MALAT1-induced CRC progression [ 91 ].…”

Section: The Role Of Malat1 In Colorectal Cancermentioning

confidence: 99%

MALAT1-related signaling pathways in colorectal cancer

Jin

et al. 2022

Cancer Cell Int

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Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcribed RNA molecules play an important role in every level of gene expression. Metastasis‐associated lung adenocarcinoma transcript‐1 (MALAT1) is a highly conserved nucleus-restricted lncRNA that regulates genes at the transcriptional and post-transcriptional levels. High expression of MALAT1 is closely related to numerous human cancers. It is generally believed that MALAT1 expression is associated with CRC cell proliferation, tumorigenicity, and metastasis. MALAT1 by targeting multiple signaling pathways and microRNAs (miRNAs) plays a pivotal role in CRC pathogenesis. Therefore, MALAT1 can be a potent gene for cancer prediction and diagnosis. In this review, we will demonstrate signaling pathways associated with MALAT1 in CRC.

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“…Kaempferol, a flavonoid compound with strong anticancer effects, also induce gastric cancer cell death by activating IRE1-JNK-CHOP pathway [32]. However, the activation of IRE1-XBP-1 may enhance the migration ability of colorectal cancer cells and thus promote the progression of colorectal cancer [33]. As for pancreatic cancer, the IRE1α-XBP1 signaling pathway has previously been shown to contribute to pancreatic cancer cell invasion in xenograft models [34].…”

Section: Ire1mentioning

confidence: 99%

The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer

et al. 2021

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Digestive cancer is one of the leading causes of cancer mortality in the world. Despite a number of studies being conducted, the exact mechanism for treating digestive cancer has not yet been fully understood. To survive, digestive cancer cells are subjected to various internal and external adverse factors, such as hypoxia, nutritional deficiencies or drug toxicity, resulting in accumulation of misfolded and unfolded protein in endoplasmic reticulum (ER) lumen further leading to ER stress and the unfolded protein response (UPR). During the last years, studies on the relationship between ER stress and microRNAs (miRNAs) has burst on the scene. miRNAs are non-coding RNAs with a length of 21~22nucleotides involved in post-transcriptional regulation of gene expression, which could be regarded as oncomiRs (tumor inducers) and tumor suppressors regulating cancer cell proliferation, invasion, and apoptosis by differently affecting the expression of genes related to cancer cell signaling. Therefore, investigating the interaction between ER stress and miRNAs is crucial for developing effective cancer treatment and prevention strategies. In this review, we mainly discuss miRNAs focusing on its regulation, role in ER stress induced apoptosis in Digestive cancer, expound the underlying mechanism, thus provides a theoretical foundation for finding new therapeutic targets of digestive cancer.

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Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1

Cited by 12 publications

References 38 publications

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

MALAT1-related signaling pathways in colorectal cancer

The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer

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